Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4

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• 作者：Sung Ho Lee ; Young-Chang Cho ; Hyung Min Jeong…
• 关键词：YY1 ; YY2 ; IL ; 4 ; Th2 cell ; Constitutive factor
• 刊名：Archives of Pharmacal Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：39
• 期：4
• 页码：547-554
• 全文大小：716 KB
• 参考文献：Atchison, L., A. Ghias, F. Wilkinson, N. Bonini, and M.L. Atchison. 2003. Transcription factor YY1 functions as a PcG protein in vivo. EMBO Journal 22: 1347–1358.CrossRef PubMed PubMedCentral
  Austen, M., B. Luscher, and J.M. Luscher-Firzlaff. 1997. Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CPB)-binding protein. Journal of Biological Chemistry 272: 1709–1717.CrossRef PubMed
  Barbulescu, K., C. Becker, J.F. Schlaak, E. Schmitt, K.H.M.Z. Buschenfelde, and M.F. Neurath. 1998. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+T lymphocytes. The Journal of Immunology 160: 3642–3647.PubMed
  Brown, M.A., and J. Hural. 1997. Functions of IL-4 and control of its expression. Critical Reviews in Immunology 17: 1–32.CrossRef PubMed
  Brown, J.L., D. Mucci, M. Whiteley, M.L. Dirksen, and J.A. Kassis. 1998. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Molecular Cell 1: 1057–1064.CrossRef PubMed
  Brusselle, G.G., J.C. Kips, J.H. Tavernier, J.G. Van Der Heyden, C.A. Cuvelier, R.A. Pauwels, and H. Bluethmann. 1994. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clinical and Experimental Allergy 24: 73–80.CrossRef PubMed
  Chung, S.W., B.Y. Kang, and T.S. Kim. 2003. Inhibition of interleukin-4 production in CD4+T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. Molecular Pharmacology 64: 1169–1179.CrossRef PubMed
  Donohoe, M.E., X. Zhang, L. Mcginnis, J. Biggers, E. Li, and Y. Shi. 1999. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Molecular and Cellular Biology 19: 7237–7244.CrossRef PubMed PubMedCentral
  Galvin, K.M., and Y. Shi. 1997. Multiple mechanisms of transcriptional repression by YY1. Molecular and Cellular Biology 17: 3723–3732.CrossRef PubMed PubMedCentral
  Gordon, S.J., S. Saleque, and B.K. Birshtein. 2003. Yin Yang 1 is a lipopolysaccharide-inducible activator of the murine 3′ Igh enhancer, hs3. The Journal of Immunology 170: 5549–5557.CrossRef PubMed
  Gordon, S., G. Akopyan, H. Garban, and B. Bonavida. 2006. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25: 1125–1142.CrossRef PubMed
  Gronroos, E., A.A. Terentiev, T. Punga, and J. Ericsson. 2004. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proceedings of the National Academy of Sciences USA 101: 12165–12170.CrossRef
  Guo, J., V. Casolaro, E. Seto, W.M. Yang, C. Chang, M.C. Seminario, J. Keen, and S.N. Georas. 2001. Yin-Yang 1 activates interleukin-4 gene expression in T cells. Journal of Biological Chemistry 276: 48871–48878.CrossRef PubMed
  Guo, J., X. Lin, M.A. Williams, Q. Hamid, and S.N. Georas. 2008. Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses. Journal of Allergy and Clinical Immunology 122: 195–201.CrossRef PubMed
  He, Y., J. Dupree, J. Wang, J. Sandoval, J. Li, H. Liu, Y. Shi, K.A. Nave, and P. Casaccia-Bonnefil. 2007. The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron 55: 217–230.CrossRef PubMed PubMedCentral
  Hiromura, M., C.H. Choi, N.A. Sabourin, H. Jones, D. Bachvarov, and A. Usheva. 2003. YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). Journal of Biological Chemistry 278: 14046–14052.CrossRef PubMed
  Ho, I.C., M.R. Hodge, J.W. Rooney, and L.H. Glimcher. 1996. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85: 973–983.CrossRef PubMed
  Hwang, S.S., Y.U. Kim, S. Lee, S.W. Jang, M.K. Kim, B.H. Koh, W. Lee, J. Kim, A. Souabni, M. Busslinger, and G.R. Lee. 2013. Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation. Proceedings of the National Academy of Sciences USA 110: 276–281.CrossRef
  Kaplan, M.H., U. Schindler, S.T. Smiley, and M.J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4: 313–319.CrossRef PubMed
  Kiani, A., F.J. Garcia-Cozar, I. Habermann, S. Laforsch, T. Aebischer, G. Ehninger, and A. Rao. 2001. Regulation of interferon-gamma gene expression by nuclear factor of activated T cells. Blood 98: 1480–1488.CrossRef PubMed
  Kim, J.D., C. Faulk, and J. Kim. 2007. Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1. Nucleic Acids Research 35: 3442–3452.CrossRef PubMed PubMedCentral
  Mordvinov, V.A., G.T. Schwenger, R. Fournier, M.L. De Boer, S.E. Peroni, A.D. Singh, S. Karlen, J.W. Holland, and C.J. Sanderson. 1999. Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells. Journal of Allergy and Clinical Immunology 103: 1125–1135.CrossRef PubMed
  Mosmann, T.R., and R.L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7: 145–173.CrossRef PubMed
  Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. The Journal of Immunology 136: 2348–2357.PubMed
  Nguyen, N., X. Zhang, N. Olashaw, and E. Seto. 2004. Molecular cloning and functional characterization of the transcription factor YY2. Journal of Biological Chemistry 279: 25927–25934.CrossRef PubMed
  Oei, S.L., and Y. Shi. 2001. Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage. Biochemical and Biophysical Research Communications 285: 27–31.CrossRef PubMed
  Parronchi, P., D. Macchia, M.P. Piccinni, P. Biswas, C. Simonelli, E. Maggi, M. Ricci, A.A. Ansari, and S. Romagnani. 1991. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proceedings of the National Academy of Sciences USA 88: 4538–4542.CrossRef
  Parronchi, P., M. De Carli, R. Manetti, C. Simonelli, M.P. Piccinni, D. Macchia, E. Maggi, G. Del Prete, M. Ricci, and S. Romagnani. 1992. Aberrant interleukin (IL)-4 and IL-5 production in vitro by CD4+ helper T cells from atopic subjects. European Journal of Immunology 22: 1615–1620.CrossRef PubMed
  Petkova, V., M.J. Romanowski, I. Sulijoadikusumo, D. Rohne, P. Kang, T. Shenk, and A. Usheva. 2001. Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells. Journal of Biological Chemistry 276: 7932–7936.CrossRef PubMed
  Pisaneschi, G., S. Ceccotti, M.L. Falchetti, S. Fiumicino, F. Carnevali, and E. Beccari. 1994. Characterization of FIII/YY1, a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes. Biochemical and Biophysical Research Communications 205: 1236–1242.CrossRef PubMed
  Ranger, A.M., M.R. Hodge, E.M. Gravallese, M. Oukka, L. Davidson, F.W. Alt, F.C. De La Brousse, T. Hoey, M. Grusby, and L.H. Glimcher. 1998. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 8: 125–134.CrossRef PubMed
  Rezai-Zadeh, N., X. Zhang, F. Namour, G. Fejer, Y.D. Wen, Y.L. Yao, I. Gyory, K. Wright, and E. Seto. 2003. Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes & Development 17: 1019–1029.CrossRef
  Seto, E., B. Lewis, and T. Shenk. 1993. Interaction between transcription factors Sp1 and YY1. Nature 365: 462–464.CrossRef PubMed
  Shi, Y., E. Seto, L.S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67: 377–388.CrossRef PubMed
  Shi, Y., J.S. Lee, and K.M. Galvin. 1997. Everything you have ever wanted to know about Yin Yang 1. Biochimica et Biophysica Acta 1332: F49–F66.PubMed
  Shrivastava, A., S. Saleque, G.V. Kalpana, S. Artandi, S.P. Goff, and K. Calame. 1993. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 262: 1889–1892.CrossRef PubMed
  Sokol, C.L., G.M. Barton, A.G. Farr, and R. Medzhitov. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunology 9: 310–318.CrossRef PubMed PubMedCentral
  Song, Z., V. Casolaro, R. Chen, S.N. Georas, D. Monos, and S.J. Ono. 1996. Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene. The Journal of Immunology 156: 424–429.PubMed
  Swain, S.L. 1993. IL4 dictates T-cell differentiation. Research in Immunology 144: 616–620.CrossRef PubMed
  Sweetser, M.T., T. Hoey, Y.L. Sun, W.M. Weaver, G.A. Price, and C.B. Wilson. 1998. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells. Journal of Biological Chemistry 273: 34775–34783.CrossRef PubMed
  Thomas, M.J., and E. Seto. 1999. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236: 197–208.CrossRef PubMed
  Wang, J., M.F. Shannon, and I.G. Young. 2006. A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes. International Immunology 18: 313–323.CrossRef PubMed
  Wang, X., Y. Feng, L. Xu, Y. Chen, Y. Zhang, D. Su, G. Ren, J. Lu, and B. Huang. 2008. YY1 restrained cell senescence through repressing the transcription of p16. Biochimica et Biophysica Acta 1783: 1876–1883.CrossRef PubMed
  Wilkinson, F.H., K. Park, and M.L. Atchison. 2006. Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Proceedings of the National Academy of Sciences USA 103: 19296–19301.CrossRef
  Yant, S.R., W. Zhu, D. Millinoff, J.L. Slightom, M. Goodman, and D.L. Gumucio. 1995. High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster. Nucleic Acids Research 23: 4353–4362.CrossRef PubMed PubMedCentral
  Yao, Y.L., W.M. Yang, and E. Seto. 2001. Regulation of transcription factor YY1 by acetylation and deacetylation. Molecular and Cellular Biology 21: 5979–5991.CrossRef PubMed PubMedCentral
  Ye, J., M. Cippitelli, L. Dorman, J.R. Ortaldo, and H.A. Young. 1996. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Molecular and Cellular Biology 16: 4744–4753.CrossRef PubMed PubMedCentral
  Zhang, D.H., L. Cohn, P. Ray, K. Bottomly, and A. Ray. 1997. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. Journal of Biological Chemistry 272: 21597–21603.CrossRef PubMed
  Zhou, Q., R.W. Gedrich, and D.A. Engel. 1995. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. Journal of Virology 69: 4323–4330.PubMed PubMedCentral
  
• 作者单位：Sung Ho Lee (1)
  Young-Chang Cho (2)
  Hyung Min Jeong (1)
  Kyung Hee Kim (3)
  Hyun Jin Choi (4)
  Kwang Youl Lee (1)
  Bok Yun Kang (1)
  
  1. College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea
  2. College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea
  3. Department of Food and Nutrition, Mokpo National University, Muan, Jeonnam, Republic of Korea
  4. College of Pharmacy, CHA University, Seongnam, Gyeonggi, Republic of Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is regulated by inducible or constitutive factors. Yin-Yang (YY)-1 is one of constitutive transcription factors binding to the IL-4 promoter. The recently identified YY2 protein is similar to YY1, with both sharing high levels of homology in their zinc finger motifs. However, the role of YY2 in T cells is unclear. YY1 and YY2 were constitutively expressed in EL4 T cells, and their expression was not dependent on stimulation. IL-4 promoter (−741/+56 fragment) activity was enhanced by YY1, but inhibited by YY2. The enhanced IL-4 promoter activity by YY1 was reduced by simultaneous expression of YY2. In addition, the DNA binding affinity of YY1 to the IL-4 promoter was adversely affected by YY2. Our results suggest that YY1 and YY2 exert opposing effects on the IL-4 promoter as they compete for the same DNA binding sites.