Radiation-induced osteosarcoma after Gamma Knife surgery for vestibular schwannoma: a case report and literature review

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• 作者：Young-Bem Se ; Dong Gyu Kim ; Sung-Hye Park ; Hyun-Tai Chung
• 关键词：Stereotactic radiosurgery ; Gamma Knife radiosurgery ; Vestibular schwannoma ; Radiation ; induced sarcoma ; Osteosarcoma
• 刊名：Acta Neurochirurgica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：159
• 期：2
• 页码：385-391
• 全文大小：
• 刊物主题：Neurosurgery; Interventional Radiology; Neuroradiology; Neurology; Surgical Orthopedics; Minimally Invasive Surgery;
• 出版者：Springer Vienna
• ISSN：0942-0940
• 卷排序：159

文摘

We present a rare case of radiation-induced osteosarcoma following Gamma Knife® surgery (GKS) for a vestibular schwannoma (VS). A 49-year-old female with sporadic VS underwent GKS. Serial follow-up imaging showed that the tumor size decreased. Six years after GKS, magnetic resonance imaging demonstrated regrowth of the tumor. The tumor was removed via the retrosigmoid approach. Interestingly, the final pathology report confirmed osteosarcoma arising in schwannoma with direct transition (osteosarcoma component: 90 %, schwannoma component: 10 %). The osteosarcoma was considered to be a radiation-induced malignancy. The possibility of this rare complication should be explained to the patient before GKS, and the patient should be screened periodically after GKS.