Latitude has more significant impact on prevalence of multiple sclerosis than ultraviolet level or sunshine duration in Japanese population

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• 作者：Masako Kinoshita ; Kaoru Obata ; Masami Tanaka
• 关键词：Multiple sclerosis ; Prevalence ; Latitude ; Ultraviolet ; Actual sunshine duration
• 刊名：Neurological Sciences
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：36
• 期：7
• 页码：1147-1151
• 全文大小：527 KB
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• 作者单位：Masako Kinoshita (1)
  Kaoru Obata (2)
  Masami Tanaka (2)
  
  1. Department of Neurology, Utano National Hospital, National Hospital Organization, 8 Ondoyama-Cho, Narutaki, Ukyoku, Kyoto, 616-8255, Japan
  2. MS Center, Utano National Hospital, National Hospital Organization, Kyoto, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478

文摘

Higher latitude is known to be associated with higher prevalence of multiple sclerosis (MS). We investigated the degree of impact of latitude, ultraviolet (UV) radiation, and sunshine on the prevalence of MS in Japan, which has 47 prefectures with a variety of climates. MS prevalence in each prefecture was collected from database of the Ministry of Health, Labour, and Welfare of Japan. Latitude of each prefecture was represented by that of the capital city. Data of UV radiation level and annual actual sunshine duration were obtained from databases of Japan Meteorological Agency. We performed linear correlation analyses of MS prevalence against latitude, UV radiation, and annual actual sunshine duration. MS prevalence significantly correlated to latitude (Pearson’s correlation, r?=?0.69, p?<?0.001) and UV radiation level (r?=??.65, p?<?0.001) but not to annual actual sunshine duration (r?=??.37, p?=?0.011). Stepwise multiple linear regression analyses revealed significant correlation between MS prevalence and only latitude (p?<?0.001). While our result shows that both latitude and the UV intensity have significant relationship to MS prevalence, the stronger relevance of the former suggests an existence of risk factors other than UV radiation.