All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells
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- 作者：Ying Xu (1)
Tianyou Wang (2)
Ruihong Tang (2)
Suoqin Tang (1) - 关键词：ATRA ; Folate receptor ; Target therapy ; Leukemia
- 刊名：Tumor Biology
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：31
- 期：6
- 页码：589-595
- 全文大小：181KB
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Tianyou Wang (2)
Ruihong Tang (2)
Suoqin Tang (1)
1. Department of Pediatrics, Clinical Division of Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People’s Republic of China
2. Department of Hematology–Oncology, Capital Institute of Pediatrics, 2 Yabao Road, Chaoyang District, Beijing, 100020, People’s Republic of China - ISSN：1423-0380
文摘
The high expression of folate receptor (FR) on cancer cells might be a potential target for cancer therapy. In this study, the FR-β expression and the modulation effect of all-trans retinoic acid (ATRA) in a number of cancer cell lines were analyzed. The gateway of ATRA activity on FR-β expression was further studied by a panel of retinoid activators and inhibitors. The results revealed that ATRA was capable of upregulating the expression of FR-β protein in KG-1 cells in a dosage-dependent manner, not in KG-1a, NB4, HL60, 293, L1210, JAR, and Hela cells. FR-β mRNA expression in KG-1 cells was higher when ATRA was present in culture medium at 10??mol/L for 5?days, and it went down to baseline when ATRA was removed from the medium, vice versa. The upregulation of FR-β expression in KG-1 cells by ATRA was not associated with cell proliferation and differentiation. In addition, activators of retinoid acid receptor (RAR)α and RARγ, CD336, and CD2781 also induced FR-β expression. The induction of FR-β expression by CD336 could be inhibited by RARγ antagonist CD2665; RARβ agonist CD-417 and CD-2314 as well as retinoid X receptor (RXR) agonist LG100364 could not induce FR-β expression. These results indicate that ATRA within a certain range of concentration could reversibly induce the expression of FR-β in a dosage- and cell type-dependent manner, and its action in KG-1 cells might be associated with the signal transduction of retinoid receptor RARα and RARγ, rather than RARβ and RXRs.