A case of superficial esophageal squamous cell carcinoma invading the lamina propria mucosa with a metastatic lymph node along the celiac artery

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• 作者：Kiyonori Tanoue ; Hiroshi Okumura ; Yasuto Uchikado ; Tetsuhiro Owaki…
• 关键词：Lymph node metastasis ; Superficial esophageal cancer ; Lamina propria mucosa
• 刊名：Esophagus
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：12
• 期：3
• 页码：263-266
• 全文大小：1,062 KB
• 参考文献：1.Natsugoe S, Matsumoto M, Okumura H, Ikeda M, Ishigami S, Owaki T, Takao S, Aikou T. Prognostic factors in patients with submucosal esophageal cancer. J Gastrointest. 2004;8:631鈥?.View Article
  2.Eguchi T, Nakanishi Y, Shimoda T, Iwasaki M, Igaki H, Tachimori Y, et al. Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: analysis of 464 surgically resected cases. Mod Pathol. 2006;19:475鈥?0.PubMed View Article
  3.Japanese Society for Esophageal Disease. Guide lines for the clinical and pathologic studies on carcinoma of the esophagus. 10th ed.; 2008.
  4.Kumagai Y, Toi M, Kawada K, Kawano T. Angiogenesis in superficial esophageal squamous cell carcinoma: magnifying endoscopic observation and molecular analysis. Dig Endosc. 2010;22:259鈥?7.PubMed View Article
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  6.Ando N, Ozawa S, Kitagawa Y, Shinozawa Y, Kitajima M. Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg. 2000;232:225鈥?2.PubMed Central PubMed View Article
  7.Takahashi Y, Takeno S, Watanabe S, Kamei M, Ono K, Yamashita S, et al. Superficial esophageal squamous cell carcinoma with bulky gastric hiatus lymph node metastasis: a case report. Dig Endosc. 2009;21:262鈥?.PubMed View Article
  8.Hatakeyama T, Shiozaki A, Fujiwara H, Ichikawa D, Okamoto K, Komatsu S, et al. A case of a superficial carcinoma of the esophagus with isolated lymph node metastasis around the abdominal aorta. Surg Today. 2012;42:676鈥?0.PubMed View Article
  9.Prenzel KL, Bollshweiler E, Schr枚der W, M枚nig SP, Drebber U, Vallboehmer D, et al. Prognostic relevance of skip metastases in esophageal cancer. Ann Thorac Surg. 2010;90:1662鈥?0.PubMed View Article
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  12.Natsugoe S, Matsumoto M, Okumura H, Nakashima S, Higashi H, Uenosono Y, Ehi K, Ishigami S, Takao S, Aikou T. Initial metastatic, including micrometastatic, sites of lymph nodes in esophageal squamous cell carcinoma. J Surg Oncol. 2005;89(1):6鈥?1.PubMed View Article
  13.Natsugoe S, Nakashima S, Kijima F, Shimada M, Kusano C, Yoshinaka H, Baba M, Tkao S, Aikou T. Analysis of macroscopic appearance and p53 expression in superficial esophageal carcinoma. Hepatogastroenterology. 1999;46(28):2398鈥?04.PubMed
  14.Flamen P, Lerut A, Van Cutsem E, De Wever W, Peeters M, Stroobants S, et al. Utility of positron emission tomography for the staging of patients with potentially operable esophageal carcinoma. J Clin Oncol. 2000;181:3202鈥?0.
  15.Kita Y, Okumura H, Uchikado Y, Sasaki K, Omoto I, Matsumoto M, et al. Clinical significance of 18F-fluorodeoxyglucose positron emission tomography in superficial esophageal squamous cell carcinoma. Ann Surg Oncol. 2013;20:1646鈥?2.PubMed View Article
  
• 作者单位：Kiyonori Tanoue (1)
  Hiroshi Okumura (1)
  Yasuto Uchikado (1)
  Tetsuhiro Owaki (2)
  Masataka Matsumoto (1)
  Tetsuro Setoyama (1)
  Yoshiaki Kita (1)
  Itaru Omoto (1)
  Ken Sasaki (1)
  Takaaki Arigami (1)
  Yoshikazu Uenosono (1)
  Sumiya Ishigami (1)
  Shoji Natsugoe (1)
  
  1. Department of Digestive Surgery, and Breast and Thyroid Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan
  2. Education Center for Doctors in Remote Islands and Rural Areas, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Pathology
  Thoracic Surgery
  Surgical Oncology
  Oncology
  
• 出版者：Springer Japan
• ISSN：1612-9067

文摘

A 62-year-old man was diagnosed with superficial esophageal cancer on upper endoscopy during health screening. Endoscopic examination with iodine staining and narrow-band imaging revealed three superficial erosive lesions in the middle and lower thoracic esophagus. The depth of tumor invasion was diagnosed as shallow invasion into the submucosal layer on endoscopic ultrasonography. Since enhanced computed tomography showed a markedly swollen lymph node at the right cardia, with higher F-deoxyglucose uptake on F-deoxyglucose positron emission tomography, lymph node metastasis was suspected. Then esophagectomy with lymph node dissection was performed, and histopathologic examination of the resected specimen revealed metastasis of squamous cell carcinoma in the huge lymph node along the celiac artery. In superficial esophageal cancer with a distinct depressed lesion, horizontal extension, and especially with erosive esophagitis, the possibility of lymph node metastases should be kept in mind even the depth of tumor invasion was lamina propria mucosa.