Responses of skeletal muscles to gravitational unloading and/or reloading
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- 作者：Takashi Ohira ; Fuminori Kawano ; Tomotaka Ohira…
- 关键词：Gravitational unloading ; Responses of skeletal muscles ; Morphological ; metabolic ; and contractile properties ; Neural ; mechanical ; and metabolic factors
- 刊名：The Journal of Physiological Sciences
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：65
- 期：4
- 页码：293-310
- 全文大小：1,669 KB
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125.Ingalls CP, Warren GL, Armstrong RB (1999) Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading. J Appl Physiol 87:386鈥?90PubMed - 作者单位：Takashi Ohira (1)
Fuminori Kawano (2)
Tomotaka Ohira (3)
Katsumasa Goto (3)
Yoshinobu Ohira (4)
1. Space Biomedical Research Office, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki, 305-8505, Japan
2. Graduate School of Medicine, Osaka University, Toyonaka, Osaka, 560-0043, Japan
3. Graduate School of Health Sciences, Toyohashi SOZO University, Toyohashi, Aichi, 440-8511, Japan
4. Graduate School of Health and Sports Science, Doshisha University, Miyakodani 1-3, Tatara, Kyotanabe, Kyoto, 610-0394, Japan - 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
- 出版者：Springer Japan
- ISSN：1880-6562
文摘
Adaptation of morphological, metabolic, and contractile properties of skeletal muscles to inhibition of antigravity activities by exposure to a microgravity environment or by simulation models, such as chronic bedrest in humans or hindlimb suspension in rodents, has been well reported. Such physiological adaptations are generally detrimental in daily life on earth. Since the development of suitable countermeasure(s) is essential to prevent or inhibit these adaptations, effects of neural, mechanical, and metabolic factors on these properties in both humans and animals were reviewed. Special attention was paid to the roles of the motoneurons (both efferent and afferent neurograms) and electromyogram activities as the neural factors, force development, and/or length of sarcomeres as the mechanical factors and mitochondrial bioenergetics as the metabolic factors.