Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children

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• 作者：Mariella Valenzise ; Tommaso Aversa ; Giuseppina Zirilli…
• 关键词：Chromosomopathies ; Down’s syndrome ; Hashimoto’s thyroiditis ; Thyroid function ; Thyroid status ; Turner syndrome
• 刊名：Italian Journal of Pediatrics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：43
• 期：1
• 全文大小：450KB
• 刊物主题：Pediatrics; Maternal and Child Health;
• 出版者：BioMed Central
• ISSN：1824-7288
• 卷排序：43

文摘

Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyroid status is distinctly higher in the SH children with Hashimoto’s thyroiditis (HT). This risk is even higher in the cases with both HT-related SH and chromosomal abnormalities, such as Turner or Down’s syndrome.