SCF/c-kit signaling is required in 12-O-tetradecanoylphorbol-13-acetate-induced migration and differentiation of hair follicle melanocytes for epidermal pigmentation

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• 作者：Weiming Qiu ; Ke Yang ; Mingxing Lei ; Hongtao Yan ; Hui Tang&#8230
• 关键词：Melanocyte stem cells ; 12 ; O ; tetradecanoylphorbol ; 13 ; acetate ; Epidermal pigmentation ; Stem cell factor ; c ; kit
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：360
• 期：2
• 页码：333-346
• 全文大小：16,892 KB
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• 作者单位：Weiming Qiu (1)
  Ke Yang (2)
  Mingxing Lei (4)
  Hongtao Yan (1)
  Hui Tang (1)
  Xiufeng Bai (3)
  Guihong Yang (1)
  Xiaohua Lian (3)
  Jinjin Wu (1)
  
  1. Department of Dermatology, Daping Hospital, The Third Military Medical University, Chongqing, 400042, China
  2. Chongqing Engineering Research Center of Stem Cell Therapy, Children鈥檚 Hospital, Chongqing Medical University, Chongqing, China
  4. 鈥?11鈥?Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing, 400044, China
  3. Department of Cell Biology, The Third Military Medical University, Chongqing, 400038, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Hair follicle melanocyte stem cells (McSCs) are responsible for hair pigmentation and also function as a major melanocyte reservoir for epidermal pigmentation. However, the molecular mechanism promoting McSCs for epidermal pigmentation remains elusive. 12-O-tetradecanoylphorbol-13-acetate (TPA) mimics key signaling involved in melanocyte growth, migration and differentiation. We therefore investigated the molecular basis for the contribution of hair follicle McSCs to epidermal pigmentation using the TPA induction model. We found that repetitive TPA treatment of female C57BL/6 mouse dorsal skin induced epidermal pigmentation by increasing the number of epidermal melanocytes. Particularly, TPA treatment induced McSCs to initiate proliferation, exit the stem cell niche and differentiate. We also demonstrated that TPA promotes melanoblast migration and differentiation in vitro. At the molecular level, TPA treatment induced robust expression of stem cell factor (SCF) in keratinocytes and c-kit in melanoblasts and melanocytes. Administration of ACK2, a neutralizing antibody against the Kit receptor, suppressed mouse epidermal pigmentation, decreased the number of epidermal melanocytes, and inhibited melanoblast migration. Taken together, our data demonstrate that TPA promotes the expansion, migration and differentiation of hair follicle McSCs for mouse epidermal pigmentation. SCF/c-kit signaling was required for TPA-induced migration and differentiation of hair follicle melanocytes. Our findings may provide an excellent model to investigate the signaling mechanisms regulating epidermal pigmentation from mouse hair follicle McSCs, and a potential therapeutic option for skin pigmentation disorders.