Neurocognitive effects of proton radiation therapy in adults with low-grade glioma

详细信息    查看全文

• 作者：Janet Cohen Sherman ; Mary K. Colvin ; Sarah M. Mancuso…
• 关键词：Neurocognitive function ; Proton radiation therapy ; Low ; grade glioma ; Tumor laterality ; Neuropsychology
• 刊名：Journal of Neuro-Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：126
• 期：1
• 页码：157-164
• 全文大小：862 KB
• 参考文献：1.Smoll NR, Gautschi OP, Schatlo B et al (2012) Relative survival of patients with supratentorial low-grade gliomas. Neuro Oncol 14(8):1062鈥?069. doi:10.鈥?093/鈥媙euonc/鈥媙os144 PubMedCentral PubMed CrossRef
  2.Youland RS, Schomas DA, Brown PD et al (2013) Changes in presentation, treatment, and outcomes of adult low-grade gliomas over the past fifty years. Neuro Oncol 15(8):1102鈥?110. doi:10.鈥?093/鈥媙euonc/鈥媙ot080 PubMedCentral PubMed CrossRef
  3.Noll KR, Sullaway C, Ziu M et al (2015) Relationships between tumor grade and neurocognitive functioning in patients with glioma of the left temporal lobe prior to surgical resection. Neuro Oncol 17(4):580鈥?87. doi:10.鈥?093/鈥媙euonc/鈥媙ou233 PubMed CrossRef
  4.Kaleita TA, Wellisch DK, Cloughesy TF et al (2004) Prediction of neurocognitive outcome in adult brain tumor patients. J Neurooncol 67(1鈥?):245鈥?53PubMed CrossRef
  5.Raysi Dehcordi S, Mariano M, Mazza M et al (2013) Cognitive deficits in patients with low and high grade gliomas. J Neurosurg Sci 57(3):259鈥?66PubMed
  6.Surma-aho O, Niemela M, Vilkki J et al (2001) Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients. Neurology 56(10):1285鈥?290PubMed CrossRef
  7.Douw L, Klein M, Fagel SS et al (2009) Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol 8(9):810鈥?18. doi:10.鈥?016/鈥婼1474-4422(09)70204-2 PubMed CrossRef
  8.Correa DD, DeAngelis LM, Shi W et al (2007) Cognitive functions in low-grade gliomas: disease and treatment effects. J Neurooncol 81(2):175鈥?84. doi:10.鈥?007/鈥媠11060-006-9212-3 PubMed CrossRef
  9.Klein M (2012) Neurocognitive functioning in adult WHO grade II gliomas: impact of old and new treatment modalities. Neuro Oncol 14(Suppl 4):iv17鈥搃v24. doi:10.鈥?093/鈥媙euonc/鈥媙os161 PubMedCentral PubMed CrossRef
  10.Taphoorn MJ, Klein M (2004) Cognitive deficits in adult patients with brain tumours. Lancet Neurol 3(3):159鈥?68. doi:10.鈥?016/鈥婼1474-4422(04)00680-5 PubMed CrossRef
  11.Correa DD, Shi W, Thaler HT et al (2008) Longitudinal cognitive follow-up in low grade gliomas. J Neurooncol 86(3):321鈥?27. doi:10.鈥?007/鈥媠11060-007-9474-4 PubMed CrossRef
  12.Laack NN, Brown PD, Ivnik RJ et al (2005) Cognitive function after radiotherapy for supratentorial low-grade glioma: a North Central Cancer Treatment Group prospective study. Int J Radiat Oncol Biol Phys 63(4):1175鈥?183PubMed CrossRef
  13.Klein M, Heimans JJ, Aaronson NK et al (2002) Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study. Lancet 360(9343):1361鈥?368PubMed CrossRef
  14.Brown PD, Cerhan JH (2009) Same, better, or worse? Neurocognitive effects of radiotherapy for low-grade gliomas remain unknown. Lancet Neurol 8(9):779鈥?81. doi:10.鈥?016/鈥婼1474-4422(09)70205-4 PubMed CrossRef
  15.Levin WP, Kooy H, Loeffler JS et al (2005) Proton beam therapy. Br J Cancer 93(8):849鈥?54PubMedCentral PubMed CrossRef
  16.Shih HA, Sherman JC, Nachtigall LB et al (2015) Proton therapy for low-grade gliomas: results from a prospective trial. Cancer 121(10):1712鈥?719. doi:10.鈥?002/鈥媍ncr.鈥?9237 PubMed CrossRef
  17.Jimenez RB, Sethi R, Depauw N et al (2013) Proton radiation therapy for pediatric medulloblastoma and supratentorial primitive neuroectodermal tumors: outcomes for very young children treated with upfront chemotherapy. Int J Radiat Oncol Biol Phys 87(1):120鈥?26. doi:10.鈥?016/鈥媕.鈥媔jrobp.鈥?013.鈥?5.鈥?17 PubMed CrossRef
  18.Greenberger BA, Pulsifer MB, Ebb DH et al (2014) Clinical outcomes and late endocrine, neurocognitive, and visual profiles of proton radiation for pediatric low-grade gliomas. Int J Radiat Oncol Biol Phys 89(5):1060鈥?068. doi:10.鈥?016/鈥媕.鈥媔jrobp.鈥?014.鈥?4.鈥?53 PubMed CrossRef
  19.Macdonald SM, Sethi R, Lavally B et al (2013) Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients. Neuro Oncol 15(11):1552鈥?559. doi:10.鈥?093/鈥媙euonc/鈥媙ot121 PubMedCentral PubMed CrossRef
  20.van den Bent MJ, Wefel JS, Schiff D et al (2011) Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas. Lancet Oncol 12(6):583鈥?93. doi:10.鈥?016/鈥婼1470-2045(11)70057-2 PubMed CrossRef
  21.Calamia M, Markon K, Tranel D (2013) The robust reliability of neuropsychological measures: meta-analyses of test-retest correlations. Clin Neuropsychol 27(7):1077鈥?105. doi:10.鈥?080/鈥?3854046.鈥?013.鈥?09795 PubMed CrossRef
  22.Shaw EG, Wang M, Coons SW et al (2012) Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. J Clin Oncol 30(25):3065鈥?070. doi:10.鈥?200/鈥婮CO.鈥?011.鈥?5.鈥?598 PubMedCentral PubMed CrossRef
  
• 作者单位：Janet Cohen Sherman (1)
  Mary K. Colvin (2)
  Sarah M. Mancuso (2)
  Tracy T. Batchelor (3)
  Kevin S. Oh (4)
  Jay S. Loeffler (4)
  Beow Y. Yeap (5)
  Helen A. Shih (4)
  
  1. Department of Psychiatry and Neurology, Psychology Assessment Center, Massachusetts General Hospital, 1 Bowdoin Square, 7th Floor, Boston, MA, 02114, USA
  2. Department of Psychiatry, Psychology Assessment Center, Massachusetts General Hospital, 1 Bowdoin Square, 7th Floor, Boston, MA, 02114, USA
  3. Department of Neurology, Massachusetts General Hospital, 30 Fruit Street, Boston, MA, 02114, USA
  4. Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, Boston, MA, 02114, USA
  5. Department of Medicine, Massachusetts General Hospital, 30 Fruit Street, Boston, MA, 02114, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

To understand neurocognitive effects of proton radiation therapy (PRT) in patients with low-grade glioma, we evaluated 20 patients who received this therapy prospectively and over 5 years with a comprehensive neuropsychological battery. 20 patients were evaluated at baseline and at yearly intervals for up to 5 years with a battery of neuropsychological measures that assessed intellectual, attention, executive, visuospatial and memory functions as well as mood and functional status. We evaluated change in cognitive functioning over time. We analyzed the relationship between cognitive performance and tumor location and also examined whether patients鈥?performance differed from that reported in a study of normative practice effects. Overall, patients exhibited stability in cognitive functioning. Tumor location played a role in performance; those with tumors in the left hemisphere versus in the right hemisphere were more impaired at baseline on verbal measures (p < .05). However, we found greater improvement in verbal memory over time in patients with left than with right hemisphere tumors (p < .05). Results of our study, the first to investigate, in depth, neurocognitive effects of PRT in adults with low-grade gliomas, are promising. We hypothesize that the conformal advantage of PRT may contribute to preservation of cognitive functioning, although larger sample sizes and a longer period of study are required. Our study also highlights the need to consider normative practice effects when studying neurocognitive functioning in response to treatment over time, and the need to utilize comprehensive neuropsychological batteries given our findings that differentiate patients with left and right hemisphere tumors. Keywords Neurocognitive function Proton radiation therapy Low-grade glioma Tumor laterality Neuropsychology