Multifunctional nano-sized fullerenes for advanced tumor therapy
详细信息 查看全文
- 作者：Yu Seok Youn ; Dong Sup Kwag ; Eun Seong Lee
- 关键词：Fullerene ; Polymer conjugate ; Reactive oxygen species ; Tumor therapy
- 刊名：Journal of Pharmaceutical Investigation
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：47
- 期：1
- 页码：1-10
- 全文大小：830KB
- 刊物主题：Biomedicine, general;
- 出版者：Springer Netherlands
- ISSN：2093-6214
- 卷排序：47
文摘
There is an increasing demand for the development of functional photosensitizing nano-sized drugs. Fullerene, one of the new carbon molecules, has been considered to be a useful and versatile material for this purpose. Notably, fullerenes are water-insoluble, and they readily aggregate in aqueous solution. Therefore, fullerenes usually have been coupled with water-soluble, biocompatible, biodegradable polymers (e.g., polysaccharides, proteins, and other functional polymers), achieving their improved water-solubility and biocompatible properties. In particular, when fullerenes are paired with tumor-targeting ligands or stimuli-responsive polymers, these conjugates exhibit enhanced tumor recognition ability and improved tumor inhibition. Some groups encapsulated fullerenes into liposomes or nanoemulsions for various pharmaceutical purposes. This review provides an in-depth understanding of fullerene/polymer nanoparticles for effective fullerene-mediated tumor therapy.