Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer

详细信息    查看全文

• 作者：Kristina P. S?rensen (1) (2)
  Mads Thomassen (1) (2)
  Qihua Tan (1) (3)
  Martin Bak (4)
  S?ren Cold (5)
  Mark Burton (1) (2)
  Martin J. Larsen (1) (2)
  Torben A. Kruse (1) (2)
  
• 关键词：HOTAIR ; Breast cancer ; Prognosis ; Gene expression ; Long non ; coding RNA ; Metastasis
• 刊名：Breast Cancer Research and Treatment
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：142
• 期：3
• 页码：529-536
• 全文大小：
• 作者单位：Kristina P. S?rensen (1) (2)
  Mads Thomassen (1) (2)
  Qihua Tan (1) (3)
  Martin Bak (4)
  S?ren Cold (5)
  Mark Burton (1) (2)
  Martin J. Larsen (1) (2)
  Torben A. Kruse (1) (2)
  
  1. Department of Clinical Genetics, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark
  2. Human Genetics, Clinical Institute, University of Southern Denmark, Odense, Denmark
  3. Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark
  4. Department of Pathology, Odense University Hospital, Odense, Denmark
  5. Department of Oncology, Odense University Hospital, Odense, Denmark
  
• ISSN：1573-7217

文摘

Expression of HOX transcript antisense intergenic RNA (HOTAIR)? long non-coding RNA?as been examined in a variety of human cancers, and overexpression of HOTAIR is correlated with poor survival among breast, colon, and liver cancer patients. In this retrospective study, we examine HOTAIR expression in 164 primary breast tumors, from patients who do not receive adjuvant treatment, in a design that is paired with respect to the traditional prognostic markers. We show that HOTAIR expression differs between patients with or without a metastatic endpoint, respectively. Survival analysis shows that high HOTAIR expression in primary tumors is significantly associated with worse prognosis independent of prognostic markers (P?=?0.012, hazard ratio (HR) 1.747). This association is even stronger when looking only at estrogen receptor (ER)-positive tumor samples (P?=?0.0086, HR 1.985). In ER-negative tumor samples, we are not able to detect a prognostic value of HOTAIR expression, probably due to the limited sample size. These results are successfully validated in an independent dataset with similar associations (P?=?0.018, HR 1.825). In conclusion, our findings suggest that HOTAIR expression may serve as an independent biomarker for the prediction of the risk of metastasis in ER-positive breast cancer patients.