Neural summation in human motor cortex by subthreshold transcranial magnetic stimulations

详细信息    查看全文

• 作者：Xiaoming Du ; Fow-Sen Choa ; Ann Summerfelt ; Malle A. Tagamets…
• 关键词：Subthreshold ; Summation ; TMS ; Paired pulse ; M1
• 刊名：Experimental Brain Research
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：233
• 期：2
• 页码：671-677
• 全文大小：332 KB
• 参考文献：1. Amassian VE, Quirk GJ, Stewart M (1990) A comparison of corticospinal activation by magnetic coil and electrical stimulation of monkey motor cortex. Electroencephalogr Clin Neurophysiol 77:390-01 CrossRef
  2. Barker AT, Jalinous R, Freeston IL (1985) Non-invasive magnetic stimulation of human motor cortex. Lancet 1:1106-107 CrossRef
  3. Brasil-Neto JP, McShane LM, Fuhr P, Hallett M, Cohen LG (1992) Topographic mapping of the human motor cortex with magnetic stimulation: factors affecting accuracy and reproducibility. Electroencephalogr Clin Neurophysiol 85:9-6 CrossRef
  4. Cash S, Yuste R (1998) Input summation by cultured pyramidal neurons is linear and position-independent. J Neurosci 18:10-5
  5. Cash S, Yuste R (1999) Linear summation of excitatory inputs by CA1 pyramidal neurons. Neuron 22:383-94 CrossRef
  6. Darling WG, Wolf SL, Butler AJ (2006) Variability of motor potentials evoked by transcranial magnetic stimulation depends on muscle activation. Exp Brain Res 174:376-85 CrossRef
  7. Di Lazzaro V, Rothwell JC, Oliviero A, Profice P, Insola A, Mazzone P, Tonali P (1999) Intracortical origin of the short latency facilitation produced by pairs of threshold magnetic stimuli applied to human motor cortex. Exp Brain Res 129:494-99 CrossRef
  8. Di Lazzaro V, Oliviero A, Meglio M, Cioni B, Tamburrini G, Tonali P, Rothwell JC (2000) Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex. Clin Neurophysiol 111:794-99 CrossRef
  9. Du X, Chen L, Zhou K (2012) The role of the left posterior parietal lobule in top -down modulation on space-based attention: a transcranial magnetic stimulation study. Hum Brain Mapp 33:2477-486 CrossRef
  10. Du X, Summerfelt A, Chiappelli J, Holcomb HH, Hong LE (2014) Individualized brain inhibition and excitation profile in response to paired-pulse TMS. J Mot Behav 46:39-8 CrossRef
  11. Ginanneschi F, Del Santo F, Dominici F, Gelli F, Mazzocchio R, Rossi A (2005) Changes in corticomotor excitability of hand muscles in relation to static shoulder positions. Exp Brain Res 161:374-82 CrossRef
  12. Hallett M (2007) Transcranial magnetic stimulation: a primer. Neuron 55:187-99 CrossRef
  13. Hanajima R, Ugawa Y, Terao Y, Enomoto H, Shiio Y, Mochizuki H, Furubayashi T, Uesugi H, Iwata NK, Kanazawa I (2002) Mechanisms of intracortical I-wave facilitation elicited with paired-pulse magnetic stimulation in humans. J Physiol 538:253-61 CrossRef
  14. Ilic TV, Meintzschel F, Cleff U, Ruge D, Kessler KR, Ziemann U (2002) Short-interval paired-pulse inhibition and facilitation of human motor cortex: the dimension of stimulus intensity. J Physiol 545:153-67 CrossRef
  15. Kammer T, Beck S, Thielscher A, Laubis-Herrmann U, Topka H (2001) Motor thresholds in humans: a transcranial magnetic stimulation study comparing different pulse waveforms, current directions and stimulator types. Clin Neurophysiol 112:250-58 CrossRef
  16. Kaneko K, Kawai S, Fuchigami Y, Morita H, Ofuji A (1996) The effect of current direction induced by transcranial magnetic stimulation on the corticospinal excitability in human brain. Electroencephalogr Clin Neurophysiol 101:478-82
  17. Kujirai T, Caramia MD, Rot
• 作者单位：Xiaoming Du (1)
  Fow-Sen Choa (2)
  Ann Summerfelt (1)
  Malle A. Tagamets (1)
  Laura M. Rowland (1)
  Peter Kochunov (1)
  Paul Shepard (1)
  L. Elliot Hong (1)
  
  1. Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD, 21228, USA
  2. The Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1106

文摘

Integration of diverse synaptic inputs is a basic neuronal operation that relies on many neurocomputational principles, one of which is neural summation. However, we lack empirical understanding of neuronal summation in the human brains in vivo. Here, we explored the effect of neural summation on the motor cortex using two subthreshold pulses of transcranial magnetic stimulation (TMS), each with intensities ranging from 60 to 95?% of the resting motor threshold (RMT) and interstimulus interval (ISI) varying from 1 to 25?ms. We found that two subthreshold TMS pulses can produce suprathreshold motor response when ISIs were less than 10?ms, most prominent at 1, 1.5 and 3?ms. This facilitatory, above-threshold response was evident when the intensity of the subthreshold pulses was above 80?% of RMT but was absent as the intensity was 70?% or below. Modeling of the summation data across intensity suggested that they followed an exponential function with excellent model fitting. Understanding the constraints for inducing summation of subthreshold stimulations to generate above-threshold response may have implications in modeling neural operations and potential clinical applications.