Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients

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• 作者：Detlef Degner ; Merle Haust ; Johannes Meller…
• 关键词：Thyroid diseases ; Autoimmune thyroiditis ; Hashimoto disease ; Depression ; Outpatients ; Psychiatry
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：265
• 期：1
• 页码：67-72
• 全文大小：214 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Psychiatry
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-8491

文摘

Thyroid diseases are often associated with psychiatric disorders. The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-4?%. A clinical study was conducted to evaluate the association between autoimmune thyroiditis and depression in psychiatric outpatients. Fifty-two patients with depression and nineteen patients with schizophrenia (serving as control group), attending a psychiatric outpatient unit, were included. In addition to the measurement of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, antithyroid peroxidase (anti-TPO) antibodies, and anti-thyroglobulin antibodies, ultrasound examination of the thyroid gland was performed. The proportion of pathologically increased anti-TPO levels in patients with depression was high. Furthermore, the distribution of pathologically increased anti-TPO levels was significantly (χ 2?=?5.5; p?=?0.019) different between patients with depression (32.7?%) and patients with schizophrenia (5.3?%). In a gender- and age-adjusted logistic regression, the odds ratio of uni- or bipolar patients with depression for an autoimmune thyroiditis was ten times higher (95?% CI?=?1.2-5.3) when compared with schizophrenia patients. TSH basal level did not differ between patients with depression and patients with schizophrenia. Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis (in combination with a hypoechoic thyroid in ultrasonography) with uni- or bipolar depression. It should be noted that the routinely measured TSH level is not sufficient in itself to diagnose this relevant autoimmune comorbidity.