Overlapping Morphologic and Immunohistochemical Features of Hashimoto Thyroiditis and IgG4-Related Thyroid Disease

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• 作者：Philipp W. Raess ; Arlette Habashi ; Edward El Rassi ; Mira Milas…
• 关键词：Hashimoto thyroiditis ; Fibrosing variant ; IgG4 ; related disease ; Thyroid
• 刊名：Endocrine Pathology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：26
• 期：2
• 页码：170-177
• 全文大小：1,350 KB
• 参考文献：1.Finkelberg, D.L., et al., Autoimmune pancreatitis. N Engl J Med, 2006. 355(25): p. 2670-6.View Article PubMed
  2.Stone, J.H., Y. Zen, and V. Deshpande, IgG4-related disease. N Engl J Med, 2012. 366(6): p. 539-51.View Article PubMed
  3.Deshpande, V., et al., Consensus statement on the pathology of IgG4-related disease. Mod Pathol, 2012. 25(9): p. 1181-92.View Article PubMed
  4.Hiromatsu, Y., H. Satoh, and N. Amino, Hashimoto鈥檚 thyroiditis: history and future outlook. Hormones (Athens), 2013. 12(1): p. 12-8.
  5.Caturegli, P., A. De Remigis, and N.R. Rose, Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev, 2014. 13(4-5): p. 391-7.View Article PubMed
  6.Katz, S.M. and A.L. Vickery, Jr., The fibrous variant of Hashimoto鈥檚 thyroiditis. Hum Pathol, 1974. 5(2): p. 161-70.View Article PubMed
  7.Dahlgren, M., et al., Riedel鈥檚 thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res (Hoboken), 2010. 62(9): p. 1312-8.View Article
  8.Pusztaszeri, M., et al., Riedel鈥檚 thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4 related sclerosing disease? Thyroid, 2012.
  9.Harach, H.R. and E.D. Williams, Fibrous thyroiditis--an immunopathological study. Histopathology, 1983. 7(5): p. 739-51.View Article PubMed
  10.Frank, R., et al., Multifocal fibrosing thyroiditis and its association with papillary thyroid carcinoma using BRAF pyrosequencing. Endocr Pathol, 2014. 25(3): p. 236-40.View Article PubMed
  11.Fellegara, G. and J. Rosai, Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity. Am J Surg Pathol, 2015. 39(3): p. 416-24.View Article PubMed
  12.Watanabe, T., et al., Clinical features of a new disease concept, IgG4-related thyroiditis. Scand J Rheumatol, 2013. 42(4): p. 325-30.View Article PubMed
  13.Li, Y., et al., Distinct clinical, serological, and sonographic characteristics of hashimoto鈥檚 thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab, 2010. 95(3): p. 1309-17.View Article PubMed
  14.Li, Y., et al., Immunohistochemistry of IgG4 can help subclassify Hashimoto鈥檚 autoimmune thyroiditis. Pathol Int, 2009. 59(9): p. 636-41.View Article PubMed
  15.Li, Y., et al., Distinct histopathological features of Hashimoto鈥檚 thyroiditis with respect to IgG4-related disease. Mod Pathol, 2012. 25(8): p. 1086-97.View Article PubMed
  16.Deshpande, V., et al., Fibrosing variant of Hashimoto thyroiditis is an IgG4 related disease. J Clin Pathol, 2012. 65(8): p. 725-8.View Article PubMed
  17.Zhang, J., et al., A classification of Hashimoto鈥檚 thyroiditis based on immunohistochemistry for IgG4 and IgG. Thyroid, 2014. 24(2): p. 364-70.View Article PubMed
  18.Kawashima, S.T., et al., Serum levels of IgG and IgG4 in Hashimoto thyroiditis. Endocrine, 2014. 45(2): p. 236-43.View Article PubMed
  19.Strehl, J.D., A. Hartmann, and A. Agaimy, Numerous IgG4-positive plasma cells are ubiquitous in diverse localised non-specific chronic inflammatory conditions and need to be distinguished from IgG4-related systemic disorders. J Clin Pathol, 2011. 64(3): p. 237-43.View Article PubMed
  20.Kojima, M., et al., Distribution of IgG4- and/or IgG-positive plasma cells in Hashimoto鈥檚 thyroiditis: an immunohistochemical study. Pathobiology, 2010. 77(5): p. 267-72.View Article PubMed
  21.Wu, Z., et al., Molecular analysis of HLA-DQ and -DP genes in caucasoid patients with Hashimoto鈥檚 thyroiditis. Tissue Antigens, 1994. 43(2): p. 116-9.View Article PubMed
  22.McLeod, D.S., et al., Variation in rates of autoimmune thyroid disease by race/ethnicity in US military personnel. JAMA, 2014. 311(15): p. 1563-5.View Article PubMed
  23.Ito, M., et al., Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease. Pathol Int, 2011. 61(10): p. 589-92.View Article PubMed
  24.Cheuk, W. and J.K. Chan, Lymphadenopathy of IgG4-related disease: an underdiagnosed and overdiagnosed entity. Semin Diagn Pathol, 2012. 29(4): p. 226-34.View Article PubMed
  25.Cheuk, W., et al., Lymphadenopathy of IgG4-related sclerosing disease. Am J Surg Pathol, 2008. 32(5): p. 671-81.View Article PubMed
  26.Grimm, K.E., et al., Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells. Mod Pathol, 2012. 25(3): p. 480-91.View Article PubMed
  27.Rollins-Raval, M.A., et al., Increased numbers of IgG4-positive plasma cells may rarely be seen in lymph nodes of patients without IgG4-related sclerosing disease. Int J Surg Pathol, 2012. 20(1): p. 47-53.View Article PubMed
  28.Ferry, J.A., IgG4-related lymphadenopathy and IgG4-related lymphoma: moving targets. Diagnostic Histopathology, 2013. 19(4): p. 128-139.View Article
  29.Wallace, Z.S., et al., Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations. Ann Rheum Dis, 2014.
  
• 作者单位：Philipp W. Raess (1)
  Arlette Habashi (1)
  Edward El Rassi (2)
  Mira Milas (3)
  David A. Sauer (1) (2)
  Megan L. Troxell (1)
  
  1. Department of Pathology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA
  2. Department of Otolaryngology, Oregon Health & Science University, Portland, OR, 97239, USA
  3. Department of Surgery, Oregon Health & Science University, Portland, OR, 97239, USA
  
• 刊物主题：Pathology; Endocrinology; Oncology;
• 出版者：Springer US
• ISSN：1559-0097

文摘

Immunoglobulin G4-related disease (IgG4-RD) is an emerging clinicopathologic entity characterized by both IgG4+ plasma cell infiltration and fibrosis in one or more organs, prototypically pancreas or salivary/lacrimal glands. IgG4-RD in the thyroid (IgG4-RTD) is an area of active study, and the relationship between IgG4-RTD and Hashimoto thyroiditis is not fully delineated due to their overlapping histologic features. Retrospective review was performed of all thyroidectomy cases demonstrating lymphocytic inflammation at a single institution over a 4-year period. Approximately half (23/38) of patients had a clinical diagnosis of Hashimoto thyroiditis (HT). Nine of the 38 patients had increased absolute and relative numbers of IgG4+ plasma cells. Patients with a clinical diagnosis of HT had increased lymphoplasmacytic inflammation, but the relative proportion of IgG4+ plasma cells was not increased compared to patients without HT. There was no correlation between IgG4 levels and the amount of fibrosis in patients with or without HT. Patients identified as having the fibrosing variant of HT were not more likely to have increased levels of IgG4+ plasma cells than those without. There is significant morphologic and immunohistochemical overlap between HT and IgG4-RTD. Future studies to identify specific characteristics of IgG4-RTD involving the thyroid are necessary to accurately define this entity.