Association of SIPA1 545 C > T polymorphism with survival in Chinese women with metastatic breast cancer
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- 作者：Renling Pei (1247)
Ye Xu (1247)
Yan Wei (1247)
Tao Ouyang (1247)
Jinfeng Li (1247)
Tianfeng Wang (1247)
Zhaoqing Fan (1247)
Tie Fan (1247)
Benyao Lin (1247)
Yuntao Xie (1247) - 关键词：SIPA1 ; polymorphism ; metastatic breast cancer ; survival
- 刊名：Frontiers of Medicine
- 出版年：2013
- 出版时间：March 2013
- 年：2013
- 卷：7
- 期：1
- 页码：138-142
- 全文大小：112KB
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Ye Xu (1247)
Yan Wei (1247)
Tao Ouyang (1247)
Jinfeng Li (1247)
Tianfeng Wang (1247)
Zhaoqing Fan (1247)
Tie Fan (1247)
Benyao Lin (1247)
Yuntao Xie (1247)
1247. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Beijing Cancer Hospital & Institute, Peking University Cancer Hospital, Beijing, 100142, China
文摘
It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C > T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C > T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C > T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C > T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1 545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI = 1.12-.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.