Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: initial experience

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• 作者：Chan Hong Moon (1)
  Alessandro Furlan (1)
  Jung-Hwan Kim (1) (2)
  Tiejun Zhao (3)
  Ron Shapiro (4)
  Kyongtae Ty Bae (1) (2)
  
• 关键词：Sodium MRI ; Dual ; tuned proton/sodium RF coil ; Transplanted kidney ; Sodium concentration ; Cortico ; medullary sodium gradient
• 刊名：European Radiology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：24
• 期：6
• 页码：1320-1326
• 全文大小：
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• 作者单位：Chan Hong Moon (1)
  Alessandro Furlan (1)
  Jung-Hwan Kim (1) (2)
  Tiejun Zhao (3)
  Ron Shapiro (4)
  Kyongtae Ty Bae (1) (2)
  
  1. Department of Radiology, University of Pittsburgh, 200 Lothrop Street, Presby South tower Suite 3950, Pittsburgh, PA, 15213, USA
  2. Department of Bioengineering, University of Pittsburgh, 300 Technology Dr, Pittsburgh, PA, 15213, USA
  3. MR R&D Collaborations, Siemens Medical Solutions USA, Inc, 3501 Fifth Ave, Pittsburgh, PA, 15213, USA
  4. Department of Surgery, Thomas E. Starzl Transplantation Institute, UPMC Montefiore 7S, 3459 Fifth Ave, Pittsburgh, PA, 15213, USA
  
• ISSN：1432-1084

文摘

Objectives To compare sodium (23Na) characteristics between native and transplanted kidneys using dual-tuned proton (1H)/sodium MRI. Methods Six healthy volunteers and six renal transplant patients (3 normal function, 3 acute allograft rejection) were included. Proton/sodium MRI was obtained at 3?T using a dual-tuned coil. Signal to noise ratio (SNR), sodium concentration ([23Na]) and cortico-medullary sodium gradient (CMSG) were measured. Reproducibility of [23Na] measurement was also tested. SNR, [23Na] and CMSG of the native and transplanted kidneys were compared. Results Proton and sodium images of kidneys were successfully acquired. SNR and [23Na] measurements of the native kidneys were reproducible at two different sessions. [23Na] and CMSG of the transplanted kidneys was significantly lower than those of the native kidneys: 153.5?±-1.9 vs. 192.9?±-.6?mM (P--.002) and 8.9?±-.5 vs. 10.5?±-.9?mM/mm (P--.041), respectively. [23Na] and CMSG of the transplanted kidneys with normal function vs. acute rejection were not statistically different. Conclusions Sodium quantification of kidneys was reliably performed using proton/sodium MRI. [23Na] and CMSG of the transplanted kidneys were lower than those of the native kidneys, but without a statistically significant difference between patients with or without renal allograft rejection. Key Points -Dual-tuned proton/sodium RF coil enables co-registered proton and sodium MRI. -Structural and sodium biochemical property can be acquired by dual-tuned proton/sodium MRI. -Sodium and sodium gradient of kidneys can be measured by dual-tuned MRI. -Sodium concentration was lower in transplanted kidneys than in native kidneys. -Sodium gradient of transplanted kidneys was lower than for native kidneys.