Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes
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- 作者：Anne S. Koponen (1)
Juha E. Peltonen (1) (2)
Marja K. P?ivinen (2)
Jyrki M. Aho (2)
Harriet J. H?gglund (1)
Arja L. Uusitalo (2)
Harri J. Lindholm (3)
Heikki O. Tikkanen (1) (2) - 关键词：Diabetes ; Red cell mass ; Haemoglobin ; Blood volume ; Maximal oxygen uptake ; Physical activity
- 刊名：European Journal of Applied Physiology
- 出版年：2013
- 出版时间：May 2013
- 年：2013
- 卷：113
- 期：5
- 页码：1181-1188
- 全文大小：246KB
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Juha E. Peltonen (1) (2)
Marja K. P?ivinen (2)
Jyrki M. Aho (2)
Harriet J. H?gglund (1)
Arja L. Uusitalo (2)
Harri J. Lindholm (3)
Heikki O. Tikkanen (1) (2)
1. Department of Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Paasikivenkatu 4, 00250, Helsinki, Finland
2. Foundation for Sports and Exercise Medicine, Paasikivenkatu 4, 00250, Helsinki, Finland
3. Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250, Helsinki, Finland - ISSN：1439-6327
文摘
Blood O2 carrying capacity affects aerobic capacity (VO2max). Patients with type 1 diabetes have a risk for anaemia along with renal impairment, and they often have low VO2max. We investigated whether total haemoglobin mass (tHb-mass) and blood volume (BV) differ in men with type 1 diabetes (T1D, n?=?12) presently without complications and in healthy men (CON, n?=?23) (age-, anthropometry-, physical activity-matched), to seek an explanation for low VO2max. We determined tHb-mass, BV, haemoglobin concentration ([Hb]), and VO2max in T1D and CON. With similar (mean?±?SD) [Hb] (144 vs. 145?g?l?), T1D had lower tHb-mass (10.1?±?1.4 vs. 11.0?±?1.1?g?kg?, P?<?0.05), BV (76.8?±?9.5 vs. 83.5?±?8.3?ml?kg?, P?<?0.05) and VO2max (35.4?±?4.8 vs. 44.9?±?7.5?ml?kg??min?, P?<?0.001) than CON. VO2max correlated with tHb-mass and BV both in T1D (r?=?0.71, P?<?0.01 and 0.67, P?<?0.05, respectively) and CON (r?=?0.54, P?<?0.01 and 0.66, P?<?0.001, respectively), but not with [Hb]. Linear regression slopes were shallower in T1D than CON both between VO2max and tHb-mass (2.4 and 3.6?ml?kg??min? vs. g?kg?, respectively) and VO2max and BV (0.3 and 0.6?ml?kg??min? vs. g?kg?, respectively), indicating that T1D were unable to reach similar VO2max than CON at a given tHb-mass and BV. In conclusion, low tHb-mass and BV partly explained low VO2max in T1D and may provide early and more sensitive markers of blood O2 carrying capacity than [Hb] alone.