The effect of cooling on the acetylcholine-induced current of identified Helix pomatia Br neuron

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• 作者：Miodrag Nedeljkovic (1)
  Gordana Kartelija (1)
  Lidija Radenovic (1) (2)
  Natasa Todorovic (1)
  
• 关键词：Acetylcholine ; Cooling ; Identified neuron ; Inward current ; Temperature
• 刊名：Journal of Comparative Physiology A
• 出版年：2005
• 出版时间：May 2005
• 年：2005
• 卷：191
• 期：5
• 页码：455-460
• 全文大小：264KB
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• 作者单位：Miodrag Nedeljkovic (1)
  Gordana Kartelija (1)
  Lidija Radenovic (1) (2)
  Natasa Todorovic (1)
  
  1. Department of Neurophysiology, Institute for Biological Research, Belgrade University, Belgrade, Serbia and Montenegro
  2. Department of Physiology and Biochemistry Faculty of Biology, University of Belgrade, p.f.52, Studentski trg 16, Belgrade, Serbia and Montenegro
  

文摘

The Br neuron of the snail Helix pomatia, involved in neuronal regulation of various homeostatic and adaptive mechanisms, represents an interesting model for studying effects of temperature changes on neuronal activity of poikilotherms. The acetylcholine (ACh) induces a transient, inward dose-dependent current in the identified Br neuron. In the work presented, we analyses the effects of cooling on the ACh-induced inward current. The amplitude of ACh-induced inward current was markedly decreased after cooling and the speed of the decay of ACh response was decreased. Sensitivity to cooling of Ach-activated current on the Br neuron is mediated by a mechanism that does not involve change in the apparent receptor affinity or the cooperativity of binding.