Ultrasound-assisted dispersive liquid–liquid microextraction method combined with HPLC-fluorescence detection for the determination of glycyrrhetinic acid in liquorice and liquorice-derived food products

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• 作者：Jinmao You ; Hongliang Wu ; Guoliang Li ; Lian Xia…
• 关键词：Liquorice ; Glycyrrhetinic acid ; Ultrasound ; assisted dispersive liquid–liquid microextraction ; Pre ; column derivatization
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：13
• 期：2
• 页码：359-367
• 全文大小：1,327 KB
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• 作者单位：Jinmao You (1) (2)
  Hongliang Wu (1) (2)
  Guoliang Li (1)
  Lian Xia (1)
  Mei Zhao (1)
  Shuaimin Lu (1)
  Weiheng Kong (1)
  
  1. Key Laboratory of Life-Organic Analysis of Shandong Province, Qufu Normal University, Qufu, People’s Republic of China
  2. Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, People’s Republic of China
  
• 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1735-2428

文摘

A sensitive and inexpensive method involving ultrasound-assisted dispersive liquid–liquid microextraction (UA-DLLME) and pre-column derivatization followed by high-performance liquid chromatography with fluorescence detection (HPLC-FLD) was developed for the analysis of glycyrrhetinic acid. In this work, glycyrrhetinic acid could be obtained by hydrolyzing glycyrrhizic acid to remove glucuronic acid and subsequently extracted by UA-DLLME using chloroform and acetone as the extraction and disperser solvents, respectively. The sample extraction was firstly concentrated to dry under nitrogen and then rapidly derivatized with 2-(12-oxobenzo[b]acridin-5(12H)-yl)-ethyl-4-toluenesulfonate (BAETS) after the UA-DLLME. The prime parameters influencing the UA-DLLME and derivatization procedure were optimized using response surface methodology. Under the optimum conditions, the proposed method has a better linearity in a wider range of 6–300 ng mL−1 and a high square of correlation coefficient (R 2) at 0.9994. Limit of detection and limit of quantification were found to be 1.7 ng mL−1 and 5.8 ng mL−1, respectively. The proposed method was applied to the analysis of glycyrrhetinic acid in liquorice, liquorice apricot and sugar plum samples. For the analysis of the spiked samples, the spiked recoveries were in the range of 90.4–103.0 % with RSD less than 5.18 %. All results demonstrated that the UA-DLLME-HPLC-FLD (ultrasound-assisted dispersive liquid–liquid microextraction-high-performance liquid chromatography with fluorescence detection) was a sensitive, accurate, efficient analytical method for the determination of glycyrrhetinic acid. Keywords Liquorice Glycyrrhetinic acid Ultrasound-assisted dispersive liquid–liquid microextraction Pre-column derivatization