Pharmacokinetic Significance of Renal OAT3 (SLC22A8) for Anionic Drug Elimination in Patients with Mesangial Proliferative Glomerulonephritis
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- 作者：Yuji Sakurai ; Hideyuki Motohashi ; Ken Ogasawara ; Tomohiro Terada ; Satohiro Masuda ; Toshiya Katsura ; Noriko Mori ; Motokazu Matsuura ; Toshio Doi and Atsushi Fukatsu ; et al.
- 关键词：organic anion transporter ; human kidney ; renal diseases ; real ; time PCR ; renal clearance
- 刊名：Pharmaceutical Research
- 出版年：2005
- 出版时间：December 2005
- 年：2005
- 卷：22
- 期：12
- 页码：2016-2022
- 全文大小：412 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Pharmacology and Toxicology
Pharmacy
Biochemistry
Medical Law
Biomedical Engineering - 出版者：Springer Netherlands
- ISSN：1573-904X
文摘
Purpose Our previous studies showed that the mRNA level of human organic anion transporter (hOAT) 3 in the kidney was correlated with the rate of elimination of an anionic antibiotic cefazolin. However, the correlation coefficient was not so high. In the present study, therefore, we enrolled more patients to examine whether additional factors were responsible for the correlation.