Hereditary gastrointestinal cancer

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• 作者：Keisuke Hata ; Yoko Yamamoto ; Tomomichi Kiyomatsu ; Toshiaki Tanaka…
• 关键词：Li–Fraumeni syndrome ; Familial adenomatous polyposis ; Lynch syndrome ; Hereditary diffuse gastric cancer
• 刊名：Surgery Today
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：46
• 期：10
• 页码：1115-1122
• 全文大小：638 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813
• 卷排序：46

文摘

Gastrointestinal (GI) cancer, including gastric and colorectal cancer, is a major cause of death worldwide. A substantial proportion of patients with GI cancer have a familial history, and several causative genes have been identified. Gene carriers with these hereditary GI syndromes often harbor several kinds of cancer at an early age, and genetic testing and specific surveillance may save their lives through early detection. Gastroenterologists and GI surgeons should be familiar with these syndromes, even though they are not always associated with a high penetrance of GI cancer. In this review, we provide an overview and discuss the diagnosis, genetic testing, and management of four major hereditary GI cancers: familial adenomatous polyposis, Lynch syndrome, hereditary diffuse gastric cancer, and Li–Fraumeni syndrome.