Fertility among testicular cancer survivors: a case-control study in the U.S.

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• 作者：Christopher Kim (1)
  Katherine A. McGlynn (2)
  Ruth McCorkle (3)
  Tongzhang Zheng (2)
  Ralph L. Erickson (4)
  David W. Niebuhr (4)
  Shuangge Ma (1)
  Yaqun Zhang (1) (5)
  Yana Bai (1) (6)
  Li Dai (1) (7)
  Barry I. Graubard (2)
  Briseis Kilfoy (2)
  Kathryn Hughes Barry (1) (2)
  Yawei Zhang (1)
  
• 关键词：Fertility ; Testicular cancer ; Epidemiology
• 刊名：Journal of Cancer Survivorship
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：4
• 期：3
• 页码：266-273
• 全文大小：141KB
• 参考文献：1. American Cancer Society. Inc. Cancer Reference Information 2009. Atlanta: American Cancer Society, Inc; 2009.
  2. McGlynn KA, Devesa SS, Sigurdson AJ, Brown LM, Tsao L, Tarone RE. Trends in the incidence of testicular germ cell tumors in the United States. Cancer. 2003;91(1):63-0. CrossRef
  3. Shetty G, Meistrich ML. Hormonal approaches to preservation and restoration of male fertility after cancer treatment. J Natl Cancer Inst. 2005;34:36-.
  4. Drasga RE, Einhorn LH, Williams SD, Patel DN, Stevens EE. Fertility after chemotherapy for testicular cancer. J Clin Oncol. 1983;1:179-3.
  5. Hartmann JT, Albrecht C, Schmoll HJ, Kuczyk MA, Kollmannsberger C, Bokemeyer C. Long-term effects on sexual function and fertility after treatment of testicular cancer. Br J Cancer. 1999;80:801-. CrossRef
  6. Huyghe E, Matsuda T, Daudin M, Chevreau C, Bachaud JM, Plante P, et al. Fertility after testicular cancer treatments. Results of a large multicenter study. Cancer. 2004;100(4):732-. CrossRef
  7. Fossa SD, Ous S, Abyholm T, Norman N, Loeb M. Post-treatment fertility in patients with testicular cancer. Br J Urol. 1985;57(2):210-. CrossRef
  8. Fossa SD, Kravdal O. Fertility in Norwegian testicular cancer patients. BJC. 2000;82(3):737-1. CrossRef
  9. Hansen SW, Berthelsen JG, von der Maase H. Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastine, and bleomycin versus surveillance. J Clin Oncol. 1990;8:1695-.
  10. Lampe H, Horwich A, Norman A, Nicholls J, Dearnaley DP. Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol. 1997;15:239-5.
  11. Brydoy M, Fossa SD, Klepp O, Bremnes RM, Wist EA, Wentzel-Larsen T, et al. Paternity following treatment for testicular cancer. JNCI. 2005;97(21):1580-.
  12. Arai Y, Kawakita M, Okada Y, Yoshida O. Sexuality and fertility in long-term survivors of testicular cancer. J Clin Onc. 1997;15:1444-.
  13. McGlynn KA, Sakoda LC, Rubertone MV, Sesterhenn IA, Lyu C, Graubard BI, et al. Body size, dairy consumption, puberty, and risk of testicular cancer germ cell tumors. Am J Epidemiol. 2007;165(4):355-3. CrossRef
  14. Baniel J, Foster RS, Rowland RG, Bihrle R, Donohue JP. Testis cancer: complications of post-chemotherapy retroperitoneal lymph node dissection. J Urol. 1995;153(3):976-0. CrossRef
  15. Arai Y, Ishitoya S, Okubo K, Aoki Y, Okada T, Maeda H, et al. Nerve-sparing retroperitoneal lymph node dissection for metastatic testicular cancer. Int J Urol. 1997;4(5):487-2. CrossRef
  16. Rieker PP, Edbril SD, Garnick MB. Curative testis cancer therapy: psychosocial sequelae. J Clin Onc. 1985;3:1117-6.
  17. Greil AL. Infertility and psychological distress: a critical review of the literature. Soc Sci Med. 1997;45(11):1679-04. CrossRef
  18. Andrews FM, Abbey A, Halman LJ. Is the fertility-problem stress different? The dynamics of stress in fertile and infertile couples. Fertil Steril. 1993;57(6):1247-3.
  19. Sharpe RM, Skakkeb?k NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993;341:1392-. CrossRef
  20. Schover LR, Rybicki LA, Martin BA, Bringelsen KA. Having children after cancer. Cancer. 1999;86(4):697-09. CrossRef
  21. Hartmann JT, Albrecht C, Schmoll HJ, et al. Long-term effects on sexual function and fertility after treatment of testicular cancer. Br J Cancer. 1999;80:801-. CrossRef
  22. Spermon JR, Kiemeney LALM, Meuleman EJH, Ramos L, Wetzels AMM, Witjes JA. Fertility in men with testicular germ cell tumors. Fertil Steril. 2003;79(3):1543-. CrossRef
  23. Gradishar WJ, Schilsky RL. Effects of cancer treatment on the reproductive system. CRC Crit Rev Oncol Hematol. 1988;8:153-1. CrossRef
  24. Van Voorhis BJ, Sparks AET, Allen BD, Stovall DW, Syrop CH, Chapler FK. Cost-effectiveness of infertility treatments: a cohort study. Fertil Steril. 1997;67(5):830-. CrossRef
  25. TRICARE Beneficiaries. http://www.tricare.mil
  26. Department of Veterans Affairs. http://www.va.gov
  
• 作者单位：Christopher Kim (1)
  Katherine A. McGlynn (2)
  Ruth McCorkle (3)
  Tongzhang Zheng (2)
  Ralph L. Erickson (4)
  David W. Niebuhr (4)
  Shuangge Ma (1)
  Yaqun Zhang (1) (5)
  Yana Bai (1) (6)
  Li Dai (1) (7)
  Barry I. Graubard (2)
  Briseis Kilfoy (2)
  Kathryn Hughes Barry (1) (2)
  Yawei Zhang (1)
  
  1. Yale School of Public Health, Yale University, 60 College Street, LEPH 440, New Haven, CT, 06520, USA
  2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
  3. Yale School of Nursing, Yale University, New Haven, CT, USA
  4. Walter Reed Army Institute of Research, Forest Glen, MD, USA
  5. Gansu Provincial Design and Research Institute of Environmental Science, Lanzhou, Gansu, China
  6. Department of Epidemiology and Biostatistics, Lanzhou University School of Public Health, Lanzhou, China
  7. National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China
  

文摘

Introduction Testicular germ cell tumors (TGCT) disproportionately affect men between the ages of 15 and 49?years, when reproduction is typical. Although TGCT treatment directly affects gonadal tissues, it remains unclear whether there are long-term effects on fertility. Methods To examine post-TGCT treatment fertility, study participants in a previously conducted case-control study were contacted. The men were initially enrolled in the US Servicemen’s Testicular Tumor Environmental and Endocrine Determinants (STEED) study between 2002 and 2005. A total of 246 TGCT cases and 236 controls participated in the current study and completed a self-administered questionnaire in 2008-009. Results TGCT cases were significantly more likely than controls to experience fertility distress (OR 5.23; 95% CI 1.99-3.76) and difficulty in fathering children (OR 6.41; 2.72-5.13). Cases were also more likely to be tested for infertility (OR 3.65; 95% CI 1.55-.59). Cases, however, did not differ from controls in actually fathering children (OR 1.37; 95% CI 0.88-.15). These findings were predominantly observed among nonseminoma cases and cases treated with surgery only or surgery-plus-chemotherapy. Discussion While expressing greater fertility distress, higher likelihood of fertility testing, and difficulty fathering children, these data suggest that TGCT survivors are no less likely to father children than are other men. It is possible that treatment for TGCT does not permanently affect fertility or, alternatively, that TGCT survivors attempt to father children with greater persistence or at younger ages than do other men.