Population Frequencies of the Triallelic 5HTTLPR in Six Ethnicially Diverse Samples from North America, Southeast Asia, and Africa

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• 作者：Brett C. Haberstick ; Andrew Smolen ; Redford B. Williams…
• 关键词：5HTTLPR ; Serotonin transporter ; rs25531 ; Hispanics ; Add health ; Population genetics ; Cameroon
• 刊名：Behavior Genetics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：45
• 期：2
• 页码：255-261
• 全文大小：268 KB
• 参考文献：1. Anchordoquy, HC, McGeary, C, Liu, L, Krauter, KS, Smolen, A (2003) Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behav Genet 33: pp. 73-78 CrossRef
  2. Bryc, K, Velez, C, Karafet, T, Moreno-Estrada, A, Reynolds, A, Auton, A, Hammer, M, Bustamante, CD, Ostrer, H (2010) Genome-wide patters of population structure and admixture among Hispanic/Latino populations. Proc Natl Acad Sci USA 107: pp. 8954-8961 CrossRef
  3. Conger RD, Scholfield TJ, Neppi TK (2012) Intergenerational continuity and discontinuity in harsh parenting. Parent Sci Pract 12(2-):222-31
  4. Don, RH, Cox, RT, Wainwright, BJ, Baker, K, Mattick, JS (1992) “Touchdown-PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 19: pp. 4008 CrossRef
  5. Foshee VA, Benefield TS, Puvanesarajah S, Reyes HL, Haberstick BC, Smlen A, Ennett ST, Suchindran C (2014) Self-regulatory failure and the perpetration of adolescent dating violence: examining an alcohol use by gene explanation. Aggress Behav Epub ahead of print. doi:10.1002/ab.21550
  6. Gelernter, J, Kranzler, H, Cubells, JF (1997) Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibrium in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 101: pp. 243-246 CrossRef
  7. Genovese, G, Handsaker, RE, Li, H, Kenny, EE, McCarroll, SA (2013) Mapping the human heference Genome’s missing sequence by three-way admixture in Latino genomes. Am J Hum Genet 93: pp. 411-421 CrossRef
  8. Goldman, N, Glei, DA, Lin, YH, Weinstein, M (2010) The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms. Depress Anxiety 27: pp. 260-269 CrossRef
  9. Haberstick, BC, Smolen, A, Stetler, GL, Tabor, JW, Roy, T, Casey, RH, Roy, F, Ryals, LA, Hewitt, C, Whitsel, EA, Halpern, CT, Killeya-Jones, LA, Lessem, JM, Hewitt, JK, Harris, KM (2014) Simple sequence repeats in the National Longitudinal Study of Adolescent Health: an ethnically diverse resource for genetic analysis of health and behavior. Behav Genet 44: pp. 487-497 CrossRef
  10. Harris, KM, Halpern, CT, Haberstick, BC, Smolen, A (2013) The National Longitudinal Study of Adolescent Health (Add Health) sibling pairs data. Twin Res Hum Genet 16: pp. 391-398 CrossRef
  11. Heils, A, Teufel, A, Petri, S, Stober, G, Riederer, P, Bengel, D, Lesch, KP (1996) Allelic variation of the human serotonin transporter gene expression. J Neurochem 66: pp. 2621-2624 CrossRef
  12. Hu, X, Lipsky, RH, Zhu, G, Akhtar, LA, Taubman, J, Greenberg, BD, Xu, K, Arnold, PD, Richter, MA, Kennedy, JL, Murphy, DL, Goldman, D (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78: pp. 815-826 CrossRef
  13. Kaur, D, Bishop, GD (2013) Cardiovascular responses to stress in Singapore and India. Int J Psychophysiol 87: pp. 130-140 CrossRef
  14. Lesch, KP, Bengel, D, Heils, A, Sabol, SZ, Greenberg, BD, Petri, S, Benjamin, J, Muller, CR, Hamer, DH, Murphy, DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: pp. 1527-1531 CrossRef
  15. Manichaikul, A, Palmas, W, Rodriguez, CJ, Peralta, CA, Divers, J, Guo, X, Chen, WM, Wong, Q, Williams, K, Kerr, KF, Taylor, KD, Tsai, MY, Goodarzi, MO, Sale, MM, Diez-Roux, AV, Rich, SS, Rotter, JI,
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Neurosciences
  Evolutionary Biology
  
• 出版者：Springer Netherlands
• ISSN：1573-3297

文摘

Genetic differences between populations are potentially an important contributor to health disparities around the globe. As differences in gene frequencies influence study design, it is important to have a thorough understanding of the natural variation of the genetic variant(s) of interest. Along these lines, we characterized the variation of the 5HTTLPR and rs25531 polymorphisms in six samples from North America, Southeast Asia, and Africa (Cameroon) that differ in their racial and ethnic composition. Allele and genotype frequencies were determined for 24,066 participants. Results indicated higher frequencies of the rs25531 G-allele among Black and African populations as compared with White, Hispanic and Asian populations. Further, we observed a greater number of ‘extra-long-(‘XL- 5HTTLPR alleles than have previously been reported. Extra-long alleles occurred almost entirely among Asian, Black and Non-White Hispanic populations as compared with White and Native American populations where they were completely absent. Lastly, when considered jointly, we observed between sample differences in the genotype frequencies within racial and ethnic populations. Taken together, these data underscore the importance of characterizing the L-G allele to avoid misclassification of participants by genotype and for further studies of the impact XL alleles may have on the transcriptional efficiency of SLC6A4.