Conflicting umbilical artery Doppler findings in fetuses with trisomy 21

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• 作者：A. Fl?ck ; I. Remig ; A. Müller ; J. Nadal ; C. Berg…
• 关键词：Trisomy 21 ; Down syndrome ; Doppler ; Umbilical artery ; Pulsatility index ; Small for gestational age
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：292
• 期：3
• 页码：613-617
• 全文大小：386 KB
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• 作者单位：A. Fl?ck (1)
  I. Remig (1)
  A. Müller (2)
  J. Nadal (3)
  C. Berg (1) (4)
  U. Gembruch (1)
  Annegret Geipel (1)
  
  1. Department of Obstetrics and Prenatal Medicine, University Medical School Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany
  2. Department of Pathology, University Medical School Bonn, Bonn, Germany
  3. Institute for Medical Biometry, Informatics and Epidemiology, University Medical School Bonn, Bonn, Germany
  4. Division of Prenatal Medicine and Gynecologic Ultrasound, Department of Obstetrics and Gynecology, University Medical School Cologne, Cologne, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Objective To assess differences between fetuses with isolated and non-isolated trisomy 21 in umbilical artery (UA) Doppler findings in the second and third trimester and to correlate those with placental histology. Methods Retrospective analysis of UA pulsatility index (PI) in 281 fetuses with trisomy 21. Cases were divided into isolated trisomy 21 (group I, n?=?148, 52.7?%) and non-isolated trisomy 21 (group II, n?=?133, 47.3?%). UA measurements were evaluated in five different time periods (A–E; <20?+?0 to ?5?+?0?weeks) and were assigned histopathology of the placenta. Results In 118/281 (42?%) cases, UA measurement was abnormal. The frequency of PI values above the 95th percentile increased significantly with gestational age in both groups (period A 32.9?% vs. period E 63.6?%, p?<?0.0001). There was neither a difference in abnormal UA PI values between isolated and non-isolated cases [37.8?% (56/148) vs. 46.6?% (62/133)] nor a correlation to placental findings. Conclusions Fetuses with trisomy 21 often present with elevated UA PI in the late second or third trimester, irrespective of small for gestational age growth, malformations or histopathological findings of impaired placentation.