The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice

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• 作者：Wei-Sheng Lin (1)
  Jun-Yi Chen (2)
  Jo-Chiao Wang (1)
  Liang-Yu Chen (3)
  Che-Hao Lin (4)
  Tsung-Ren Hsieh (4)
  Ming-Fu Wang (5)
  Tsai-Feng Fu (6)
  Pei-Yu Wang (1)
  
• 关键词：Ludwigia octovalvis ; Dietary restriction ; Lifespan ; AMPK
• 刊名：AGE
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：36
• 期：2
• 页码：689-703
• 全文大小：810 KB
• 参考文献：1. Alcedo J, Kenyon C (2004) Regulation of / C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41(1):45-5 CrossRef
  2. Anisimov V, Semenchenko A, Yashin A (2003) Insulin and longevity: antidiabetic biguanides as geroprotectors. Biogerontology 4(5):297-07 CrossRef
  3. Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in / C. elegans. Genes Dev 18(24):3004-009 CrossRef
  4. Araki T, Sasaki Y, Milbrandt J (2004) Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305(5686):1010-013 CrossRef
  5. Bauer JH, Goupil S, Garber GB, Helfand SL (2004) An accelerated assay for the identification of lifespan-extending interventions in / Drosophila melanogaster. Proc Natl Acad Sci U S A 101(35):12980-2985 CrossRef
  6. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117):337-42 CrossRef
  7. Bishop NA, Guarente L (2007) Two neurons mediate diet-restriction-induced longevity in / C. elegans. Nature 447(7144):545-49 CrossRef
  8. Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A (2006) Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A 103(20):7901-905 CrossRef
  9. Boyd O, Weng P, Sun X, Alberico T, Laslo M, Obenland DM, Kern B, Zou S (2011) Nectarine promotes longevity in / Drosophila melanogaster. Free Radic Biol Med 50(11):1669-678 CrossRef
  10. Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol 28(1):25-0 CrossRef
  11. Buchowski MS, Hongu N, Acra S, Wang L, Warolin J, Roberts LJ II (2012) Effect of modest caloric restriction on oxidative stress in women, a randomized trial. PLoS ONE 7(10):e47079 CrossRef
  12. Buddhan S, Sivakumar R, Dhandapani N, Ganesan B, Anandan R (2007) Protective effect of dietary squalene supplementation on mitochondrial function in liver of aged rats. Prostaglandins Leukot Essent Fatty Acids 76(6):349-55 CrossRef
  13. Chan YC, Hosoda K, Tsai CJ, Yamamoto S, Wang MF (2006) Favorable effects of tea on reducing the cognitive deficits and brain morphological changes in senescence-accelerated mice. J Nutr Sci Vitaminol (Tokyo) 52(4):266-73 CrossRef
  14. Chang CI, Kuo CC, Chang JY, Kuo YH (2004) Three new oleanane-type triterpenes from / Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. J Nat Prod 67(1):91-3 CrossRef
  15. Chen CP, Lin CC, Namba T (1989) Screening of Taiwanese crude drugs for antibacterial activity against / Streptococcus mutans. J Ethnopharmacol 27(3):285-95 CrossRef
  16. Choi JH, Kim D (2000) Effects of age and dietary restriction on lifespan and oxidative stress of SAMP8 mice with learning and memory impairments. J Nutr Health Aging 4(3):182-86
  17. Chou H-J, Lai D-M, Huang C-W, McLennan IS, Wang H-D, Wang P-Y (2013) BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro. PLoS ONE 8(3):e58441 CrossRef
  18. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325(5937):201-04 CrossRef
  19. Cruz-Morales SE, García-Saldívar NL, González-López MR, Castillo-Roberto G, Monroy J, Domínguez R (2008) Acute restriction impairs memory in the elevated T-maze (ETM) and modifies serotonergic activity in the dorsolateral striatum. Behav Brain Res 195(1):187-91 CrossRef
  20. De-Mello N, Carobrez AP (2002) Elevated T-maze as an animal model of memory: effects of scopolamine. Behav Pharmacol 13(2):139-48 CrossRef
  21. Flatt T, Min K-J, D'Alterio C, Villa-Cuesta E, Cumbers J, Lehmann R, Jones DL, Tatar M (2008) / Drosophila germ-line modulation of insulin signaling and lifespan. Proc Natl Acad Sci U S A 105(17):6368-373 CrossRef
  22. Flood JF, Morley JE (1992) Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse. J Gerontol 47(2):B52–B59 CrossRef
  23. Flood JF, Morley JE (1993) Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM). Neurobiol Aging 14(2):153-57 CrossRef
  24. Galleano M, Verstraeten SV, Oteiza PI, Fraga CG (2010) Antioxidant actions of flavonoids: thermodynamic and kinetic analysis. Arch Biochem Biophys 501(1):23-0 CrossRef
  25. Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A (2007) An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in / C. elegans. Curr Biol 17(19):1646-656 CrossRef
  26. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend / Saccharomyces cerevisiae lifespan. Nature 425(6954):191-96 CrossRef
  27. Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, SY E, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJY, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA (2013) Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 339(6124):1216-219 CrossRef
  28. Ingram DK, Anson RM, De Cabo R, Mamczarz J, Zhu MIN, Mattison J, Lane MA, Roth GS (2004) Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci 1019(1):412-23 CrossRef
  29. Kadum Yakob H, Manaf Uyub A, Fariza Sulaiman S (2012) Toxicological evaluation of 80% methanol extract of / Ludwigia octovalvis (Jacq.) P.H. Raven leaves (Onagraceae) in BALB/c mice. J Ethnopharmacol 142(3):663-68 CrossRef
  30. Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310(5751):1193-196 CrossRef
  31. Lane MA, Ingram DK, Roth GS (1998) 2-Deoxy-d -glucose feeding in rats mimics physiologic effects of calorie restriction. J Anti Aging Med 1(4):327-37 CrossRef
  32. Lee KS, Lee BS, Semnani S, Avanesian A, Um CY, Jeon HJ, Seong KM, Yu K, Min KJ, Jafari M (2010) Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in / Drosophila melanogaster. Rejuvenation Res 13(5):561-70 CrossRef
  33. Lin S-J, Defossez P-A, Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in / Saccharomyces cerevisiae. Science 289(5487):2126-128 CrossRef
  34. Lin S-J, Ford E, Haigis M, Liszt G, Guarente L (2004) Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18(1):12-6 CrossRef
  35. Lopez-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci U S A 103(6):1768-773 CrossRef
  36. Maia CSF, Ferreira VMM, Diniz JSV, Carneiro FP, de Sousa JB, da Costa ET, Tomaz C (2010) Inhibitory avoidance acquisition in adult rats exposed to a combination of ethanol and methylmercury during central nervous system development. Behav Brain Res 211(2):191-97 CrossRef
  37. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489(7415):318-21 CrossRef
  38. Miyamoto M, Kiyota Y, Yamazaki N, Nagaoka A, Matsuo T, Nagawa Y, Takeda T (1986) Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiol Behav 38(3):399-06 CrossRef
  39. Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310(5746):314-17 CrossRef
  40. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8(2):157-68 CrossRef
  41. Peng C, Chan HYE, Huang Y, Yu H, Chen Z-Y (2011) Apple polyphenols extend the mean lifespan of / Drosophila melanogaster. J Agric Food Chem 59(5):2097-106 CrossRef
  42. Qiu X, Brown K, Hirschey MD, Verdin E, Chen D (2010) Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12(6):662-67 CrossRef
  43. Santos P, Bittencourt AS, Schenberg LC, Carobrez AP (2006) Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats. Neuropharmacology 51(2):203-12 CrossRef
  44. Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, Holmbeck MA, Jafari M (2009) Decreased mitochondrial superoxide levels and enhanced protection against paraquat in / Drosophila melanogaster supplemented with / Rhodiola rosea. Free Radic Res 43(9):836-43 CrossRef
  45. Schriner SE, Lee K, Truong S, Salvadora KT, Maler S, Nam A, Lee T, Jafari M (2013) Extension of / Drosophila lifespan by / Rhodiola rosea through a mechanism independent from dietary restriction. PLoS ONE 8(5):e63886 CrossRef
  46. Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M (2007) Glucose restriction extends / Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 6(4):280-93 CrossRef
  47. Shih P-H, Chan Y-C, Liao J-W, Wang M-F, Yen G-C (2010) Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry ( / Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease. J Nutr Biochem 21(7):598-05 CrossRef
  48. Simons MJP, Koch W, Verhulst S (2013) Dietary restriction of rodents decreases aging rate without affecting initial mortality rate—a meta-analysis. Aging Cell 12(3):410-14 CrossRef
  49. Sinclair DA (2005) Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 126(9):987-002 CrossRef
  50. Slack C, Foley A, Partridge L (2012) Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in / Drosophila. PLoS ONE 7(10):e47699 CrossRef
  51. Slinkard K, Singleton VL (1977) Total phenol analysis: automation and comparison with manual methods. Am J Enol Vitic 28(1):49-5
  52. Soh J-W, Marowsky N, Nichols TJ, Rahman AM, Miah T, Sarao P, Khasawneh R, Unnikrishnan A, Heydari AR, Silver RB, Arking R (2013) Curcumin is an early-acting stage-specific inducer of extended functional longevity in / Drosophila. Exp Gerontol 48(2):229-39 CrossRef
  53. Sohal RS, Buchan PB (1981) Relationship between physical activity and life span in the adult housefly, / Musca domestica. Exp Gerontol 16(2):157-62 CrossRef
  54. Stenesen D, Suh JM, Seo J, Yu K, Lee K-S, Kim J-S, Min K-J, Graff JM (2013) Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab 17(1):101-12 CrossRef
  55. Takahashi RN, Pamplona FA, Fernandes MS (2005) The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze. Neurosci Lett 380(3):270-75 CrossRef
  56. Takeda T (2009) Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice. Neurochem Res 34(4):639-59 CrossRef
  57. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16(3):296-00 CrossRef
  58. Vivancos M, Moreno JJ (2005) Beta-sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages. Free Radic Biol Med 39(1):91-7 CrossRef
  59. Wang P-Y, Koishi K, McGeachie AB, Kimber M, MacLaughlin DT, Donahoe PK, McLennan IS (2005) Mullerian inhibiting substance acts as a motor neuron survival factor in vitro. Proc Natl Acad Sci U S A 102(45):16421-6425 CrossRef
  60. Wang P-Y, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL (2009) Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci U S A 106(23):9262-267 CrossRef
  61. Weindruch R, Walford R (1982) Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 215(4538):1415-418 CrossRef
  62. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430(7000):686-89 CrossRef
  63. Wu Z, Liu SQ, Huang D (2013) Dietary restriction depends on nutrient composition to extend chronological lifespan in budding yeast / Saccharomyces cerevisiae. PLoS ONE 8(5):e64448 CrossRef
  64. Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472(7342):230-33 CrossRef
  65. Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R (2000) Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J 14(12):1825-836 CrossRef
  66. Zheng J, Mutcherson R, Helfand SL (2005) Calorie restriction delays lipid oxidative damage in / Drosophila melanogaster. Aging Cell 4(4):209-16 CrossRef
  
• 作者单位：Wei-Sheng Lin (1)
  Jun-Yi Chen (2)
  Jo-Chiao Wang (1)
  Liang-Yu Chen (3)
  Che-Hao Lin (4)
  Tsung-Ren Hsieh (4)
  Ming-Fu Wang (5)
  Tsai-Feng Fu (6)
  Pei-Yu Wang (1)
  
  1. Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, No. 1, Sec. 1, Renai Rd., Taipei, 10051, Taiwan
  2. Institute of Neuroscience, National Chengchi University, Taipei, Taiwan
  3. Department of Biotechnology, Mingchuan University, Taoyuan, Taiwan
  4. Hsiehyu Biotech Company Ltd., Taipei, Taiwan
  5. Department of Food and Nutrition, Providence University, Taichung, Taiwan
  6. Department of Applied Chemistry, National Chinan University, Nantou, Taiwan
  
• ISSN：1574-4647

文摘

We investigated the anti-aging effects of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae), an extract of which is widely consumed as a healthful drink in a number of countries. Using the fruit fly, Drosophila melanogaster, as a model organism, we demonstrated that L. octovalvis extract (LOE) significantly extended fly lifespan on a high, but not a low, calorie diet, indicating that LOE may regulate lifespan through a dietary restriction (DR)-related pathway. LOE also attenuated age-related cognitive decline in both flies and in the senescence-accelerated-prone 8 (SAMP8) mouse, without causing any discernable negative trade-offs, including water intake, food intake, fecundity, or spontaneous motor activity. LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies. Gas chromatography–mass spectrometry (GC-MS) analyses identified 17 known molecules, of which β-sitosterol and squalene were the two most abundant. We further demonstrated that β-sitosterol was capable of extending lifespan, likely through activating AMP-activated protein kinase (AMPK) in the fat body of adult flies. Taken together, our data suggest that LOE is a potent anti-aging intervention with potential for treating age-related disorders.