Successful CT guided cryoablation of phosphaturic mesenchymal tumor in the soft tissues causing tumor-induced osteomalacia: a case report

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• 作者：Sophie Cowan ; Santiago A. Lozano-Calderon ; Raul N. Uppot ; Dipti Sajed…
• 关键词：Cryoablation ; Phosphaturic mesenchymal tumor ; Tumor ; induced osteomalacia
• 刊名：Skeletal Radiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：46
• 期：2
• 页码：273-277
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Imaging / Radiology; Orthopedics; Pathology; Nuclear Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2161
• 卷排序：46

文摘

We report the case of a 25-year-old male patient with tumor-induced osteomalacia from a 1.8-cm phosphaturic mesenchymal tumor in the right distal thigh, who was treated at our institution with a single session of CT-guided cryoablation in December 2015, which resulted in biochemical and clinical resolution. We present the clinical history, physical examination, biochemistry, functional imaging, anatomic characterization, and follow-up for clinical outcome. The response to treatment was documented in terms of normalization of serum fibroblastic growth factor 23 (FGF23) and phosphorous levels, symptomatic improvement, as well as normalization of bone mineralization on femur radiographs 3 months after the procedure. Although the first-line treatment for phosphaturic mesenchymal tumor-induced osteomalacia is wide surgical excision, CT-guided cryoablation widens the array of treatment options, especially in those patients who decline surgery or who are otherwise poor surgical candidates.