Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma

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• 作者：Ruth-Miriam Koerber ; Stefanie Andrea Erika Held…
• 关键词：Spleen tyrosine kinase (Syk) ; Syk inhibitors ; Multiple myeloma ; Plasmacell malignancy ; Tyrosine kinase ; Apoptosis ; Signal transduction Bay61 ; 3606 ; Piceatannol ; R406
• 刊名：Experimental Hematology & Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：1
• 全文大小：1,261 KB
• 刊物主题：Hematology; Oncology;
• 出版者：BioMed Central
• ISSN：2162-3619

文摘

Background Multiple myeloma (MM) is a clonal B cell malignancy characterized by proliferation of malignant plasma cells in the bone marrow. Despite high-dose melphalan therapy with autologous stem cell transplantation (ASCT) and the introduction of immunomodulatory drugs like bortezomib or lenalidomide, that have been associated with improved survival, MM is still incurable and new treatment options are needed. In B cell malignancies such as chronic lymphocytic leukaemia (CLL) or diffuse large B cell lymphoma (DLBCL), Syk (spleen tyrosine kinase) inhibitors have shown promising in vitro and first clinical results. In our study, we analyzed the potential of Syk as a target in MM.