Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer
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- 作者：Rehan Ahmad ; Maroof Alam ; Masanori Hasegawa ; Yasumitsu Uchida…
- 关键词：MUC1 ; C ; AKT ; S6K1 ; TIGAR ; Colorectal cancer
- 刊名：Molecular Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1754KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
- 卷排序：16
文摘
BackgroundColorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linked to poor outcomes in this disease. Here, we investigate the effects of the MUC1-C subunit inhibitor (GO-203), which disrupts MUC1-C homo-oligomerization, on human colorectal cancer cells.