Recent advancement of Ullmann-type coupling reactions in the formation of C–C bond

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• 作者：Shovan Mondal
• 关键词：Ullmann reaction ; Cu ; catalyst ; C–C bond formation ; Green technologies ; Natural products
• 刊名：ChemTexts
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：2
• 期：4
• 全文大小：918 KB
• 刊物类别：Chemistry/Food Science, general; Biochemistry, general; Environmental Chemistry;
• 刊物主题：Chemistry/Food Science, general; Biochemistry, general; Environmental Chemistry;
• 出版者：Springer International Publishing
• ISSN：2199-3793
• 卷排序：2

文摘

The present text discussed about the recent developments and applications of the Ullmann reaction in respect of the C–C bond formation. The major drawback of the Ullmann reaction, i.e., harsh reaction condition has recently been overcome with the development of various synthetic methodologies. Green synthetic methodologies such as metal-, ligand-, and additive free conditions, recyclable heterogenous catalysts, microwave- and ultrasound-assisted synthesis, etc. have got special importance in this field. This text lucidly describes all these recently developed synthetic methodologies which make the century old Ullmann reaction much efficient, effective, economical and attractive in the field of synthetic organic chemistry. On-surface Ullmann coupling for the C–C bond formation, i.e., invoking C–C coupling reactions on a reactive surface has been discussed. All such developments of the Ullmann C–C coupling facilitate its application in the synthesis of bio-active heterocycles, drug-like molecules and natural products which has also been discussed in this text.