H3 receptor renal expression in normal and diabetic rats

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• 作者：Alessandro Pini (1)
  Paul L. Chazot (2)
  Eleonora Veglia (3)
  Aldo Moggio (3)
  Arianna Carolina Rosa (3)
  
  1. Dipartimento di Medicina Sperimentale e Clinica Sezione di Anatomia e Istologia Universit脿 degli Studi di Firenze ; Largo Brambilla 3 ; 50134 ; Florence ; Italy
  2. School of Biological and Biomedical Sciences and Wolfson Research Institute ; Durham University ; South Road ; Durham ; DH1 3LE ; UK
  3. Dipartimento di Scienza e Tecnologia del Farmaco ; University of Turin ; Via P. Giuria 9 ; 10125 ; Turin ; Italy
  
• 关键词：Histamine H3 receptor ; Histamine ; Kidney ; Diabetes ; Collecting ducts
• 刊名：Inflammation Research
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：64
• 期：5
• 页码：271-273
• 全文大小：3,095 KB
• 参考文献：1. Rosa, AC, Grange, C, Pini, A, Katebe, MA, Benetti, E, Collino, M (2013) Overexpression of histamine H(4) receptors in the kidney of diabetic rat. Inflamm Res 62: pp. 357-365 CrossRef
  2. Markle, RA, Hollis, TM, Cosgarea, AJ (1986) Renal histamine increases in the streptozotocin-diabetic rat. Exp Mol Pathol 44: pp. 21-28 CrossRef
  3. Banks, RO, Fondacaro, JD, Schwaiger, MM, Jacobson, ED (1978) Renal histamine H1 and H2 receptors: characterization and functional significance. Am J Physiol 235: pp. F570-F575
  4. Ichikawa, I, Brenner, BM (1979) Mechanisms of action of hisamine and histamine antagonists on the glomerular microcirculation in the rat. Circ Res 45: pp. 737-745 CrossRef
  5. Sinclair, RJ, Bell, RD, Keyl, MJ (1974) Effects of prostaglandin E2 (PGE2) and histamine on renal fluid dynamics. Am J Physiol 227: pp. 1062-1066
  6. Schwertschlag, U, Hackenthal, E (1982) Histamine stimulates renin release from the isolated perfused rat kidney. Naunyn Schmiedebergs Arch Pharmacol 319: pp. 239-242 CrossRef
  7. Morini, G, Becchi, G, Shenton, FC, Chazot, PL, Grandi, D (2008) Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa. Inflamm Res 57: pp. S57-S58 CrossRef
  8. Abboud, HE, Ou, SL, Velosa, JA, Shah, SV, Dousa, TP (1982) Dynamics of renal histamine in normal rat kidney and in nephrosis induced by aminonucleoside of puromycin. J Clin Invest 69: pp. 327-336 CrossRef
  9. Francis, H, Franchitto, A, Ueno, Y, Glaser, S, DeMorrow, S, Venter, J (2007) H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest 87: pp. 473-487
  10. Pearce, D, Soundararajan, R, Trimpert, C, Kashlan, OB, Deen, PM, Kohan, DE (2015) Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol CJASN 10: pp. 135-146 CrossRef
  11. Carmosino, M, Procino, G, Nicchia, GP, Mannucci, R, Verbavatz, JM, Gobin, R (2001) Histamine treatment induces rearrangements of orthogonal arrays of particles (OAPs) in human AQP4-expressing gastric cells. J Cell Biol 154: pp. 1235-1243 CrossRef
  12. Valenti, G, Procino, G, Liebenhoff, U, Frigeri, A, Benedetti, PA, Ahnert-Hilger, G (1998) A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells. J Biol Chem 273: pp. 22627-22634 CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Pharmacology and Toxicology
  Allergology
  Dermatology
  Neurology
  Rheumatology
  
• 出版者：Birkh盲user Basel
• ISSN：1420-908X

文摘

Introduction To extend our previous observation of H4R upregulation in the kidney of diabetic rats, we evaluated in the same specimens the presence of the H3R. Materials and methods Kidney specimens from 24 8-week-old male Wistar rats (12 non-diabetic and 12 diabetic animals) were processed for both immunohistochemical and immunofluorescence analyses. Results and conclusion H3R is expressed in the apical membrane by collecting duct cells in the kidney of rats and it is significantly increased in diabetic animals. These data support the hypothesis that H3R could also mediate non-neuronal histamine effects, suggesting its involvement in fluid homeostasis.