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Regression analysis of informative current status data with the additive hazards model
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  • 作者:Shishun Zhao (1)
    Tao Hu (2)
    Ling Ma (3)
    Peijie Wang (1)
    Jianguo Sun (3)

    1. College of Mathematics
    ; Jilin University ; Changchun ; 130012 ; People鈥檚 Republic of China
    2. School of Mathematical Sciences and BCMIIS
    ; Capital Normal University ; Beijing ; 100048 ; People鈥檚 Republic of China
    3. Department of Statistics
    ; University of Missouri ; 146 Middlebush Hall ; MO ; 65211 ; USA
  • 关键词:Additive hazards model ; Current status data ; Efficient estimation ; Informative censoring
  • 刊名:Lifetime Data Analysis
  • 出版年:2015
  • 出版时间:April 2015
  • 年:2015
  • 卷:21
  • 期:2
  • 页码:241-258
  • 全文大小:214 KB
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  • 刊物类别:Mathematics and Statistics
  • 刊物主题:Statistics
    Statistics
    Statistics for Life Sciences, Medicine and Health Sciences
    Quality Control, Reliability, Safety and Risk
    Statistics for Business, Economics, Mathematical Finance and Insurance
    Operation Research and Decision Theory
  • 出版者:Springer Netherlands
  • ISSN:1572-9249
文摘
This paper discusses regression analysis of current status failure time data arising from the additive hazards model in the presence of informative censoring. Many methods have been developed for regression analysis of current status data under various regression models if the censoring is noninformative, and also there exists a large literature on parametric analysis of informative current status data in the context of tumorgenicity experiments. In this paper, a semiparametric maximum likelihood estimation procedure is presented and in the method, the copula model is employed to describe the relationship between the failure time of interest and the censoring time. Furthermore, I-splines are used to approximate the nonparametric functions involved and the asymptotic consistency and normality of the proposed estimators are established. A simulation study is conducted and indicates that the proposed approach works well for practical situations. An illustrative example is also provided.

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