A description of the hepatitis B virus genomic background in a high-prevalence area in China

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• 作者：Xiaoming Chen (1)
  Jie Gao (1)
  Zhaohua Ji (1)
  Weilu Zhang (1)
  Lei Zhang (1)
  Rui Xu (1)
  Jingxia Zhang (1)
  Fei Li (2)
  Shi Li (3)
  Shijie Hu (4)
  Lei Shang (5)
  ZhongJun Shao (1)
  Yongping Yan (1)
  
  1. Department of Epidemiology ; School of Public Health ; Fourth Military Medical University ; No. 17 ; Changle west RD ; Xi鈥檃n ; 710032 ; China
  2. Department of Cardiology ; Xijing Hospital ; The Fourth Military Medical University ; No. 17 ; Changle west RD ; Xi鈥檃n ; 710032 ; China
  3. Department of Otolaryngology ; Xijing Hospital ; The Fourth Military Medical University ; No. 17 ; Changle west RD ; Xi鈥檃n ; 710032 ; China
  4. Institute Of Neurosurgery ; Xijing Hospital ; The Fourth Military Medical University ; No. 17 ; Changle west RD ; Xi鈥檃n ; 710032 ; China
  5. Department of Statistics ; School of Public Health ; Fourth Military Medical University ; No. 17 ; Changle west RD ; Xi鈥檃n ; 710032 ; China
  
• 关键词：Hepatitis B virus ; Consensus sequences ; Clinically relevant mutations
• 刊名：Virology Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：11
• 期：1
• 全文大小：604 KB
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• 刊物主题：Virology;
• 出版者：BioMed Central
• ISSN：1743-422X

文摘

Background Hepatitis B (HB) is an important disease worldwide. Almost 350 million people are positive for Hepatitis B virus surface antigen (HBsAg), and one-third of them live in China. According to a nation-wide serosurvey in China in 2006, the prevalence of HBsAg was higher in Northwest China than in other areas. However, the epidemic HBV strains in this area are poorly studied. Results In this study, 242 complete hepatitis B virus (HBV) genome sequences were obtained from HBV asymptomatic carriers in major cities of Northwest China. The 242 HBV sequences clustered into genotypes B, C and D. Through comparison of the genotype consensus sequences, 158 genotype-dependent positions were observed in P, S and X ORFs. Clinically relevant mutation screening in this study revealed that no HBV antiviral drug resistance mutations were observed and the vaccination failure mutations were heavily underrepresented. Conclusions The role of genotype D strains in HBV prevalence should not be ignored in Northwest China. Due to low prevalence of vaccination failure mutations, it can be inferred that the genotype B, C and D strains in Northwest China may have less likelihood of vaccine escape.