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An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates
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  • 作者：H. Mulla (1) (10)
    S. Yakkundi (2)
    J. McElnay (2)
    I. Lutsar (3)
    T. Metsvaht (3) (4)
    H. Varendi (5)
    G. Nellis (3) (5)
    A. Nunn (6)
    J. Duncan (6)
    H. Pandya (7)
    M. Turner (8) (9)

    1. Department of Pharmacy     ; University Hospitals of Leicester ; Leicester ; UK
    10. Department of Pharmacy     ; Glenfield Hospital ; University Hospitals of Leicester ; Groby Road ; Leicester ; LE3 9QP ; UK
    2. Clinical & Practice Research Group     ; School of Pharmacy ; Queen鈥檚 University Belfast ; Belfast ; UK
    3. Institute of Microbiology     ; Tartu University ; Tartu ; Estonia
    4. Tartu University Hospital     ; Clinic of Anaesthesiology and Intensive Care ; Paediatric Intensive Care Unit ; Tartu ; Estonia
    5. Tartu University Hospital     ; Children鈥檚 Clinic ; Neonatal Unit ; Tartu ; Estonia
    6. Alder Hey Children鈥檚 NHS Foundation Trust     ; Liverpool ; UK
    7. Department of Infection     ; Immunity and Inflammation ; University of Leicester ; Leicester ; UK
    8. Liverpool Women鈥檚 Hospital     ; Neonatal Unit ; Liverpool ; UK
    9. Institute of Translational Medicine     ; University of Liverpool ; Liverpool ; UK
  • 关键词：exicipient ; kinetics ; methyl ; parabens ; neonates ; propyl ; parabens
  • 刊名：Pharmaceutical Research
  • 出版年：2015
  • 出版时间：March 2015
  • 年：2015
  • 卷：32
  • 期：3
  • 页码：1084-1093
  • 全文大小：377 KB
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    9. EMEA/CHMP/PEG/194810/2005 (2006) Reflection paper: formulations of choice for the paediatric population. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003782.pdf. Accessed 12 May 2013.
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    23. Yakkundi S, McElnay J, Millership J, Mulla H, Pandya H, Shah U, / et al. Use of dried blood spots to study excipient kinetics in neonates. Bioanalysis. 2011;3(24):2691鈥?. CrossRef
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    27. Patel P, Mulla H, Kairamkonda V, Spooner N, Gade S, Della Pasqua O, / et al. Dried blood spots and sparse sampling: a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants. Br J Clin Pharmacol. 2013;75(3):805鈥?3.
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  • 刊物类别：Biomedical and Life Sciences
  • 刊物主题：Biomedicine
    Pharmacology and Toxicology
    Pharmacy
    Biochemistry
    Medical Law
    Biomedical Engineering
  • 出版者：Springer Netherlands
  • ISSN：1573-904X
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