Impact of serum uric acid, albumin and their interaction on Parkinson’s disease

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• 作者：Lijun Wang ; Wei Hu ; Jun Wang ; Fangfang Fang ; Guanliang Cheng…
• 关键词：Serum uric acid ; Serum albumin ; Interaction ; Parkinson’s disease
• 刊名：Neurological Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：2
• 页码：331-336
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neurology; Neuroradiology; Neurosurgery; Psychiatry;
• 出版者：Springer Milan
• ISSN：1590-3478
• 卷排序：38

文摘

The study aimed to investigate the correlation between Parkinson’s disease (PD) and serum levels of uric acid (UA), albumin and their interaction. A cross-sectional study was conducted to evaluate the relationship of serum UA, albumin with PD. A total of 96 PD patients and 108 healthy controls were recruited at Huai’an First People’s Hospital, Nanjing Medical University. Baseline data included age, gender, body mass index (BMI), disease duration, Hoehn and Yahr scale (H&Y) stage, serum UA and albumin levels. The levels of serum UA and albumin were significantly lower in PD patients than those in controls (P = 0.001; P = 0.000). Serum albumin levels were strikingly different in H&Y group (P = 0.004). Multivariable logistic regression showed that the levels of serum UA (P = 0.001, adjusted OR 0.993, 95% CI 0.988–0.997) and albumin (P = 0.000, adjusted OR 0.513, 95% CI 0.425–0.620) were independent risk factors in PD. The receiver operating characteristic (ROC) curve analyses showed that the area under curve (AUC) for serum UA and albumin was 0.669 (95% CI 0.594–0.744) and 0.883 (95% CI 0.835–0.931), respectively. The combination of serum albumin and UA improved the AUC to 0.898 (95% CI 0.854–0.942). Serum UA and albumin levels significantly decreased in PD patients and were independent risk factors for PD. More studies are needed to confirm our findings.