Physicochemical and Biomechanical Stimuli in Cell-Based Articular Cartilage Repair
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- 作者：Holger Jahr (1) (2)
Csaba Matta (2) (3) (4)
Ali Mobasheri (2) (3) (5) (6)
1. Department of Orthopaedic Surgery ; University Hospital RWTH Aachen University ; Pauwelsstra脽e 30 ; 52074 ; Aachen ; Germany
2. The D-BOARD European Consortium for Biomarker Discovery ; Surrey ; UK
3. Department of Veterinary Preclinical Sciences ; School of Veterinary Medicine ; Faculty of Health and Medical Sciences ; University of Surrey ; Duke of Kent Building ; Guildford ; Surrey ; GU2 7XH ; UK
4. Department of Anatomy ; Histology and Embryology ; Faculty of Medicine ; University of Debrecen ; Nagyerdei krt. 98 ; Debrecen ; 4032 ; Hungary
5. Arthritis Research UK Centre for Sport ; Exercise and Osteoarthritis ; Arthritis Research UK Pain Centre ; Medical Research Council and Arthritis Research UK Centre for Musculoskeletal Ageing Research ; University of Nottingham ; Queen鈥檚 Medical Centre ; Nottingham ; NG7 2UH ; UK
6. Center of Excellence in Genomic Medicine Research (CEGMR) ; King Fahd Medical Research Center (KFMRC) ; King AbdulAziz University ; Jeddah ; 21589 ; Kingdom of Saudi Arabia - 关键词：Articular cartilage ; Cartilage repair ; Regenerative medicine ; Autologous chondrocyte implantation ; Chondrocyte metabolism ; Functional tissue engineering ; Cartilage bioengineering ; Mesenchymal stem cell ; Intracellular signaling pathways
- 刊名：Current Rheumatology Reports
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：17
- 期：3
- 全文大小：1,289 KB
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- 出版者：Springer US
- ISSN：1534-6307
文摘
Articular cartilage is a unique load-bearing connective tissue with a low intrinsic capacity for repair and regeneration. Its avascularity makes it relatively hypoxic and its unique extracellular matrix is enriched with cations, which increases the interstitial fluid osmolarity. Several physicochemical and biomechanical stimuli are reported to influence chondrocyte metabolism and may be utilized for regenerative medical approaches. In this review article, we summarize the most relevant stimuli and describe how ion channels may contribute to cartilage homeostasis, with special emphasis on intracellular signaling pathways. We specifically focus on the role of calcium signaling as an essential mechanotransduction component and highlight the role of phosphatase signaling in this context.