Involvement of adiponectin in early stage of colorectal carcinogenesis

详细信息    查看全文

• 作者：Chung Hyun Tae (6)
  Seong-Eun Kim (6)
  Sung-Ae Jung (6)
  Yang-Hee Joo (6)
  Ki-Nam Shim (6)
  Hye-Kyung Jung (6)
  Tae Hun Kim (6)
  Min-Sun Cho (7)
  Kwang Ho Kim (8)
  Joung Sook Kim (9)
  
  6. Department of Internal Medicine ; Ewha Medical Research Institute ; Ewha Womans University School of Medicine ; Seoul ; Korea
  7. Department of Pathology ; Ewha Medical Research Institue ; Ewha Womans University School of Medicine ; Seoul ; Korea
  8. Department of Surgery ; Ewha Medical Research Institute ; Ewha Womans University School of Medicine ; Seoul ; Korea
  9. Department of Health Promotion Medicine ; Ewha Medical Research Institute ; Ewha Womans University School of Medicine ; Seoul ; Korea
  
• 关键词：Adiponectin ; Adiponectin receptors ; Colorectal cancer ; Carcinogenesis
• 刊名：BMC Cancer
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：1,497 KB
• 参考文献：1. Trayhurn, P, Wood, IS (2007) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: pp. 347 CrossRef
  2. Maeda, K, Okubo, K, Shimomura, I, Funahashi, T, Matsuzawa, Y, Matsubara, K (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221: pp. 286-289 CrossRef
  3. Hu, E, Liang, P, Spiegelman, BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271: pp. 10697-10703 CrossRef
  4. Goldfine, AB, Kahn, CR (2003) Adiponectin: linking the fat cell to insulin sensitivity. Lancet 362: pp. 1431-1432 CrossRef
  5. Kadowaki, T, Yamauchi, T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26: pp. 439-451 CrossRef
  6. Hotta, K, Funahashi, T, Arita, Y, Takahashi, M, Matsuda, M, Okamoto, Y, Iwahashi, H, Kuriyama, H, Ouchi, N, Maeda, K, Nishida, M, Kihara, S, Sakai, N, Nakajima, T, Hasegawa, K, Muraguchi, M, Ohmoto, Y, Nakamura, T, Yamashita, S, Hanafusa, T, Matsuzawa, Y (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20: pp. 1595-1599 CrossRef
  7. Halleux, CM, Takahashi, M, Delporte, ML, Detry, R, Funahashi, T, Matsuzawa, Y, Brichard, SM (2001) Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun 288: pp. 1102-1107 CrossRef
  8. Arita, Y, Kihara, S, Ouchi, N, Takahashi, M, Maeda, K, Miyagawa, J, Hotta, K, Shimomura, I, Nakamura, T, Miyaoka, K, Kuriyama, H, Nishida, M, Yamashita, S, Okubo, K, Matsubara, K, Muraguchi, M, Ohmoto, Y, Funahashi, T, Matsuzawa, Y (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257: pp. 79-83 CrossRef
  9. Ouchi, N, Kihara, S, Arita, Y, Maeda, K, Kuriyama, H, Okamoto, Y, Hotta, K, Nishida, M, Takahashi, M, Nakamura, T, Yamashita, S, Funahashi, T, Matsuzawa, Y (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: pp. 2473-2476 CrossRef
  10. Kershaw, EE, Flier, JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: pp. 2548-2556 CrossRef
  11. Hug, C, Wang, J, Ahmad, NS, Bogan, JS, Tsao, TS, Lodish, HF (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 101: pp. 10308-10313 CrossRef
  12. Calle, EE, Rodriguez, C, Walker-Thurmond, K, Thun, MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348: pp. 1625-1638 CrossRef
  13. Kolonel, LN, Altshuler, D, Henderson, BE (2004) The multiethnic cohort study: exploring genes, lifestyle and cancer risk. Nat Rev Cancer 4: pp. 519-527 CrossRef
  14. Renehan, AG, Tyson, M, Egger, M, Heller, RF, Zwahlen, M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371: pp. 569-578 CrossRef
  15. Mantzoros, C, Petridou, E, Dessypris, N, Chavelas, C, Dalamaga, M, Alexe, DM, Papadiamantis, Y, Markopoulos, C, Spanos, E, Chrousos, G, Trichopoulos, D (2004) Adiponectin and breast cancer risk. J Clin Endocrinol Metab 89: pp. 1102-1107 CrossRef
  16. Dal Maso, L, Augustin, LS, Karalis, A, Talamini, R, Franceschi, S, Trichopoulos, D, Mantzoros, CS, La Vecchia, C (2004) Circulating adiponectin and endometrial cancer risk. J Clin Endocrinol Metab 89: pp. 1160-1163 CrossRef
  17. Sharma, D, Wang, J, Fu, PP, Sharma, S, Nagalingam, A, Mells, J, Handy, J, Page, AJ, Cohen, C, Anania, FA, Saxena, NK (2010) Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. Hepatology 52: pp. 1713-1722 CrossRef
  18. Perrier, S, Jarde, T (2012) Adiponectin, an anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer. Curr Med Chem 19: pp. 5501-5512 CrossRef
  19. Kim, AY, Lee, YS, Kim, KH, Lee, JH, Lee, HK, Jang, SH, Kim, SE, Lee, GY, Lee, JW, Jung, SA, Chung, HY, Jeong, S, Kim, JB (2010) Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation. Mol Endocrinol 24: pp. 1441-1452 CrossRef
  20. Ogunwobi, OO, Beales, IL (2006) Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept 134: pp. 105-113 CrossRef
  21. Wei, EK, Giovannucci, E, Fuchs, CS, Willett, WC, Mantzoros, CS (2005) Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst 97: pp. 1688-1694 CrossRef
  22. Lukanova, A, Soderberg, S, Kaaks, R, Jellum, E, Stattin, P (2006) Serum adiponectin is not associated with risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 15: pp. 401-402 CrossRef
  23. Yoneda, K, Tomimoto, A, Endo, H, Iida, H, Sugiyama, M, Takahashi, H, Mawatari, H, Nozaki, Y, Fujita, K, Yoneda, M, Inamori, M, Nakajima, N, Wada, K, Nagashima, Y, Nakagama, H, Uozaki, H, Fukayama, M, Nakajima, A (2008) Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. Oncol Rep 20: pp. 479-483
  24. Williams, CJ, Mitsiades, N, Sozopoulos, E, Hsi, A, Wolk, A, Nifli, AP, Tseleni-Balafouta, S, Mantzoros, CS (2008) Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors. Endocr Relat Cancer 15: pp. 289-299 CrossRef
  25. Hwang, MS, Yu, N, Stinson, SY, Yue, P, Newman, RJ, Allan, BB, Dornan, D (2013) miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer. PLoS One 8: pp. e66502 CrossRef
  The Asia-Pacific Perspective Redefining obesity and its treatment.
  26. Xu, XT, Xu, Q, Tong, JL, Zhu, MM, Huang, ML, Ran, ZH, Xiao, SD (2011) Meta-analysis: circulating adiponectin levels and risk of colorectal cancer and adenoma. J Dig Dis 12: pp. 234-244 CrossRef
  27. Otake, S, Takeda, H, Suzuki, Y, Fukui, T, Watanabe, S, Ishihama, K, Saito, T, Togashi, H, Nakamura, T, Matsuzawa, Y, Kawata, S (2005) Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res 11: pp. 3642-3646 CrossRef
  28. Otake, S, Takeda, H, Fujishima, S, Fukui, T, Orii, T, Sato, T, Sasaki, Y, Nishise, S, Kawata, S (2010) Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer. World J Gastroenterol 16: pp. 1252-1257 CrossRef
  29. Saltevo, J, Vanhala, M, Kautiainen, H, Kumpusalo, E, Laakso, M (2008) Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study. Diabet Med 25: pp. 747-750 CrossRef
  30. Adamczak, M, Rzepka, E, Chudek, J, Wi醛cek, A (2005) Ageing and plasma adiponectin concentration in apparently healthy males and females. Clin Endocrinol 62: pp. 114-118 CrossRef
  31. Durand, JL, Nawrocki, AR, Scherer, PE, Jelicks, LA (2012) Gender differences in adiponectin modulation of cardiac remodeling in mice deficient in endothelial nitric oxide synthase. J Cell Biochem 29: pp. 24206
  32. Lilja, M, Rolandsson, O, Norberg, M, Soderberg, S (2012) The impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance. Metab Syndr Relat Disord 10: pp. 143-151 CrossRef
  33. Tabatabaei-Malazy, O, Hasani-Ranjbar, S, Amoli, MM, Heshmat, R, Sajadi, M, Derakhshan, R, Amiri, P, Namakchian, M, Rezazadeh, E, Tavakkoly-Bazzaz, J, Keshtkar, A, Larijani, B (2010) Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index. Rev Diabet Stud 7: pp. 241-246
  34. Kern, PA, Gregorio, GBD, Lu, T, Rassouli, N, Ranganathan, G (2003) Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-a expression. Diabetes 52: pp. 1779-1785 CrossRef
  35. Wang, Y, Lam, KSL, Xu, A (2007) Adiponectin as a negative regulator in obesity-related mammary carcinogenesis. Cell Res 17: pp. 280-282 CrossRef
  36. Obeid, S, Hebbard, L (2012) Role of adiponectin and its receptors in cancer. Cancer Biol Med 9: pp. 213-220
  37. Dalamaga, M, Diakopoulos, KN, Mantzoros, CS (2012) The role of adiponectin in cancer: a review of current evidence. Endocr Rev 33: pp. 547-594 CrossRef
  38. Gialamas, SP, Petridou, ET, Tseleni-Balafouta, S, Spyridopoulos, TN, Matsoukis, IL, Kondi-Pafiti, A, Zografos, G, Mantzoros, CS (2011) Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer. Metabolism 60: pp. 1530-1538 CrossRef
  39. Fenton, JI, Birmingham, JM (2010) Adipokine regulation of colon cancer: adiponectin attenuates interleukin-6-induced colon carcinoma cell proliferation via STAT-3. Mol carcinog 49: pp. 700-709
  40. Moon, H-S, Liu, X, Nagel, JM, Chamberland, JP, Diakopoulos, KN, Brinkoetter, MT, Hatziapostolou, M, Wu, Y, Robson, SC, Iliopoulos, D, Mantzoros, CS (2013) Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut 62: pp. 561-570 CrossRef
  41. Byeon, JS, Jeong, JY, Kim, MJ, Lee, SM, Nam, WH, Myung, SJ, Kim, JG, Yang, SK, Kim, JH, Suh, DJ (2010) Adiponectin and adiponectin receptor in relation to colorectal cancer progression. Int J Cancer 127: pp. 2758-2767 CrossRef
  42. Fujisawa, T, Endo, H, Tomimoto, A, Sugiyama, M, Takahashi, H, Saito, S, Inamori, M, Nakajima, N, Watanabe, M, Kubota, N, Yamauchi, T, Kadowaki, T, Wada, K, Nakagama, H, Nakajima, A (2008) Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 57: pp. 1531-1538 CrossRef
  43. Mifflin, RC, Pinchuk, IV, Saada, JI, Powell, DW (2011) Intestinal myofibroblasts: targets for stem cell therapy. Am J Physiol 300: pp. G684-G696
  44. Konstantinopoulos, PA, Vandoros, GP, Karamouzis, MV, Gkermpesi, M, Sotiropoulou-Bonikou, G, Papavassiliou, AG (2007) EGF-R is expressed and AP-1 and NF-魏B are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. Anal Cell Pathol 29: pp. 477-482
  45. Alexis, D, Christelle, G, Giulio, G (2004) The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int J Dev Biol 48: pp. 509-517 CrossRef
  46. Zavadil, J, Haley, J, Kalluri, R, Muthuswamy, SK, Thompson, E (2008) Epithelial-mesenchymal transition. Cancer Res 68: pp. 9574-9577 CrossRef
  47. Takeuchi, T, Adachi, Y, Ohtsuki, Y, Furihata, M (2007) Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease. Med Mol Morphol 40: pp. 115-120 CrossRef
  48. Berx, G, van Roy, F (2009) Involvement of members of the cadherin superfamily in cancer. Cold Spring Harbor Perspect Biol 1: pp. 6 CrossRef
  49. J-z, R, J-r, H (2012) Correlation between T-cadherin gene expression and aberrant methylation of T-cadherin promoter in human colon carcinoma cells. Med Oncol 29: pp. 915-918 CrossRef
  50. Hwang, J-T, Ha, J, Park, I-J, Lee, S-K, Baik, HW, Kim, YM, Park, OJ (2007) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett 247: pp. 115-121 CrossRef
  51. Vetvik, KK, Sonerud, T, Lindeberg, M, Luders, T, Storkson, RH, Jonsdottir, K, Frengen, E, Pietilainen, KH, Bukholm, I (2014) Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism 63: pp. 672-681 CrossRef
  52. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/14/811/prepub
  
• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background Although altered levels of adiponectin have been reported as a potential risk factor in colorectal cancer (CRC), the importance of the role played by adiponectin in colorectal carcinogenesis has not been established. We sought to examine the expression pattern of adiponectin and adiponectin receptors (AdipoRs) in the normal-adenoma-carcinoma sequence and to assess the implications of adiponectin in colorectal carcinogenesis. Methods Serum adiponectin concentrations, and the mRNA and protein expression of adiponectin and AdipoRs were examined using serum and tissues from patients with CRC, advanced adenoma, and a normal colon. mRNA expression of AdipoRs and epithelial-mesenchymal transition regulators including E-cadherin, cyclooxygenase-2 (COX-2) and T-cadherin were examined in HCT116 cells treated with adiponectin. Results Serum adiponectin concentrations in patients with advanced adenoma and CRC were lower than those in controls. Adiponectin mRNA was not detected in colonic tissue, whereas AdipoRs mRNA was lower in advanced adenoma and CRC than that in normal colon tissues. Immunohistochemical staining demonstrated that adiponectin was expressed in spindle-shaped cells of the subepithelial layer in normal colon tissues, whereas ill-defined overexpression of adiponectin was seen in the stroma of advanced adenoma and CRC tissues. AdipoRs expression was strong in normal epithelium, but weak to negative in the epithelia of CRC tissues. Adiponectin downregulated COX-2 mRNA expression in vitro, but upregulated T-cadherin in HCT116 cells. Conclusions Systemic adiponectin and local AdipoRs expression in the colon may be associated with anti-tumorigenesis during the early stages of CRC. These findings offer new insight into understanding the relationship between adiponectin and colorectal carcinogenesis.