Population In Vitro-In Vivo Correlation Model Linking Gastrointestinal Transit Time, pH, and Pharmacokinetics: Itraconazole as a Model Drug

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• 作者：Ahmad Y. Abuhelwa ; Stuart Mudge ; David Hayes ; Richard N. Upton…
• 刊名：Pharmaceutical Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：33
• 期：7
• 页码：1782-1794
• 全文大小：2,943 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X
• 卷排序：33

文摘

PurposeTo establish an in vitro-in vivo correlation (IVIVC) model for Sporanox and SUBA-itraconazole formulations and to understand the impact of gastrointestinal (GI) pH and transit times on itraconazole dissolution and absorption.