Efficacy of vaccination with La Sota strain vaccine to control Newcastle disease in village chickens in Nepal

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• 作者：Sulochana Shrestha ; Mamta Dhawan…
• 关键词：Newcastle disease virus ; Vaccination ; Immunogenicity ; Chickens
• 刊名：Tropical Animal Health and Production
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：49
• 期：2
• 页码：439-444
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Zoology; Veterinary Medicine/Veterinary Science;
• 出版者：Springer Netherlands
• ISSN：1573-7438
• 卷排序：49

文摘

The efficacy of vaccination with Newcastle disease (ND) La Sota and R₂B (Mukteswar) modified live strain vaccines was determined by experimental challenge and with ND La Sota vaccine under field conditions in Nepal. Booster vaccination with ND La Sota vaccine after a primary vaccination with ND La Sota vaccine, induced a geometric mean titre (GMT) of 5.0 log₂ haemagglutination inhibition (HI) units, compared to a GMT of 6.0 log₂ HI units following booster vaccination with R₂B vaccine 1 month after primary vaccination with ND La Sota vaccine. Both vaccines provided 100% protection against challenge with a local field ND strain. Furthermore, booster vaccination with ND La Sota vaccine induced protective levels of antibody after field use in villages in Jhapa, and no outbreaks of ND occurred during the study period. The ND La Sota modified live vaccine is immunogenic and efficacious and is a suitable vaccine for use in vaccination programmes in village chickens in the rural areas of Nepal.