Release of endothelial cell associated VEGFR2 during TGF-β modulated angiogenesis in vitro
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- 作者：M. Jarad ; E. A. Kuczynski ; J. Morrison ; A. M. Viloria-Petit…
- 关键词：Tip cell ; Vascular sprouting ; Notch1 ; Dll4 ; Smad signaling ; Microparticle
- 刊名：BMC Cell Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：2225KB
- 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2121
- 卷排序：18
文摘
BackgroundSprouting angiogenesis requires vascular endothelial proliferation, migration and morphogenesis. The process is regulated by soluble factors, principally vascular endothelial growth factor (VEGF), and via bidirectional signaling through the Jagged/Notch system, leading to assignment of tip cell and stalk cell identity. The cytokine transforming growth factor beta (TGF-β) can either stimulate or inhibit angiogenesis via its differential surface receptor signaling. Here we evaluate changes in expression of angiogenic signaling receptors when bovine aortic endothelial cells were exposed to TGF-β1 under low serum conditions.