Direct Compression of Cellulose and Lignin Isolated by a New Catalytic Treatment

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• 作者：Anna Penkina (1)
  Osmo Antikainen (2)
  Maija Hakola (3)
  Sirpa Vuorinen (3)
  Timo Repo (3)
  Jouko Yliruusi (2)
  Peep Veski (1)
  Karin Kogermann (1)
  Jyrki Hein?m?ki (1)
  
• 关键词：elasticity ; lignin ; plasticity ; pretreated cellulose ; tablet compression
• 刊名：AAPS PharmSciTech
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：14
• 期：3
• 页码：1129-1136
• 全文大小：524KB
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• 作者单位：Anna Penkina (1)
  Osmo Antikainen (2)
  Maija Hakola (3)
  Sirpa Vuorinen (3)
  Timo Repo (3)
  Jouko Yliruusi (2)
  Peep Veski (1)
  Karin Kogermann (1)
  Jyrki Hein?m?ki (1)
  
  1. Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 50411, Tartu, Estonia
  2. Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56,, Viikinkaari 5E, 00014, Helsinki, Finland
  3. Laboratory of Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Helsinki, P.O. Box 55,, A. I. Virtasen aukio 1, 00014, Helsinki, Finland
  

文摘

Tablet compression of softwood cellulose and lignin prepared by a new catalytic oxidation and acid precipitation method were investigated and compared with the established pharmaceutical direct compression excipients. Catalytic pretreated softwood cellulose (CPSC) and lignin (CPSL) were isolated from pine wood (Pinus sylvestris). The compaction studies were carried out with an instrumented eccentric tablet machine. The plasticity and elasticity of the materials under compression were evaluated using force-displacement treatment and by determining characteristic plasticity (PF) and elasticity (EF) factors. With all biomaterials studied, the PF under compression decreased exponentially as the compression force increased. The compression force applied in tablet compression did not significantly affect the elasticity of CPSC and microcrystalline cellulose (MCC) while the EF values for softwood lignins increased as compression force increased. CPSL was clearly a less plastically deforming and less compactable material than the two celluloses (CPSC and MCC) and hardwood lignin. CPSL presented deformation and compaction behaviour almost identical to that of lactose monohydrate. In conclusion, the direct tablet compression behaviour of native lignins and celluloses can greatly differ from each other depending on the source and isolation method used.