Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity
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- 作者：Vinicius Pires Rinc?o (1)
Kristie Aimi Yamamoto (1)
Nágila Maria Pontes Silva Ricardo (3)
Sandra Aguiar Soares (3)
Luzia Doretto Paccola Meirelles (2)
Carlos Nozawa (1)
Rosa Elisa Carvalho Linhares (1) - 关键词：Lentinula edodes ; Antiviral activity ; Poliovirus ; Bovine herpesvirus
- 刊名：Virology Journal
- 出版年：2012
- 出版时间：December 2012
- 年：2012
- 卷：9
- 期：1
- 全文大小：234KB
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Kristie Aimi Yamamoto (1)
Nágila Maria Pontes Silva Ricardo (3)
Sandra Aguiar Soares (3)
Luzia Doretto Paccola Meirelles (2)
Carlos Nozawa (1)
Rosa Elisa Carvalho Linhares (1)
1. Departamento de Microbiologia, Universidade Estadual de Londrina, Rod. Celso Garcia Cid., km 380, CEP, 86051-990, Londrina, Paraná, Brazil
3. Departamento de Química Organica e Inorganica, Universidade Federal do Ceará, Av. da Universidade, 2853, CEP, 60455-760, Fortaleza, Ceará, Brazil
2. Departamento de Biologia Geral, Universidade Estadual de Londrina, Rod. Celso Garcia Cid., km 380, CEP, 86051-990, Londrina, Paraná, Brazil - ISSN：1743-422X
文摘
Background Lentinula edodes, known as shiitake, has been utilized as food, as well as, in popular medicine, moreover, compounds isolated from its mycelium and fruiting body have shown several therapeutic properties. The aim of this study was to determine the antiviral activity of aqueous (AqE) and ethanol (EtOHE) extracts and polysaccharide (LeP) from Lentinula edodes in the replication of poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BoHV-1). Methods The time-of-addition assay was performed at the times -2, -1, 0, 1 and 2 h of the infection. The virucidal activity and the inhibition of viral adsorption were also evaluated. Plaque assay was used to monitor antiviral activity throughout. Results The AqE and LeP were more effective when added at 0 h of infection, however, EtOHE was more effective at the times 1 h and 2 h of the infection. AqE, EtOHE and LeP showed low virucidal activity, and the inhibition of viral adsorption was not significant. Conclusions The results allowed us to conclude that AqE, EtOHE and LeP act on the initial processes of the replication of both strains of virus.