The emerging role of Acid Sphingomyelinase in autophagy
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- 作者：Cristiana Perrotta (1)
Davide Cervia (1) (2)
Clara De Palma (1)
Emma Assi (3)
Paolo Pellegrino (1)
Maria Teresa Bassi (3)
Emilio Clementi (1) (3)
1. Unit of Clinical Pharmacology ; Department of Biomedical and Clinical Sciences 鈥淟uigi Sacco鈥?(DIBIC) ; National Research Council-Institute of Neuroscience ; University Hospital 鈥淟uigi Sacco鈥? Universit脿 di Milano ; 20157 ; Milan ; Italy
2. Department for Innovation in Biological ; Agro-food and Forest Systems (DIBAF) ; Universit脿 della Tuscia ; 01100 ; Viterbo ; Italy
3. Scientific Institute IRCCS Eugenio Medea ; 23842 ; Bosisio Parini ; Italy - 关键词：Acid Sphingomyelinase ; Autophagy ; Autophagic signalling ; Lysosomes ; Autophagy ; related diseases
- 刊名：Apoptosis
- 出版年：2015
- 出版时间：May 2015
- 年：2015
- 卷：20
- 期：5
- 页码：635-644
- 全文大小：243 KB
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107. Smith, EL, Schuchman, EH (2008) The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. Faseb J 22: pp. 3419-3431 - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology
Cancer Research
Cell Biology
Biochemistry
Virology - 出版者：Springer Netherlands
- ISSN：1573-675X
文摘
Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase (A-SMase), already known to play a fundamental role in apoptotic cell death participating in several pathophysiological conditions. In this review we analyse and discuss the relationship between autophagy and A-SMase describing how A-SMase may regulate it and defining, for the first time, the existence of an A-SMase-autophagy axis. The imbalance of this axis plays a role in cancer, nervous system, cardiovascular, and hepatic disorders.