An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions

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• 作者：Chun-Yen Liu ; Pei-Tsen Wu ; Jing-Ping Wang ; Po-Wei Fan ; Chang-Hung Hsieh…
• 关键词：Indolylquinoline ; Human non ; small ; cell ; lung ; cancer cells ; Apoptosis ; RNA interference ; p53
• 刊名：Apoptosis
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：20
• 期：11
• 页码：1471-1482
• 全文大小：2,242 KB
• 参考文献：1.Mariette C, Piessen G, Triboulet JP (2007) Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities. Lancet Oncol 8:545鈥?53CrossRef PubMed
  2.Chang A (2011) Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer 71:3鈥?0CrossRef PubMed
  3.Hida T, Ariyoshi Y, Kuwabara M, Sugiura T, Takahashi T, Takahashi T, Hosoda K et al (1993) Glutathione S-transferase pi levels in a panel of lung cancer cell lines and its relation to chemo-radiosensitivity. Jpn J Clin Oncol 23:14鈥?9PubMed
  4.Tiseo M, Boni L, Ardizzoni A (2005) Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: does cisplatin versus carboplatin make a difference? J Clin Oncol 23:6276鈥?277CrossRef PubMed
  5.Giovanella BC, Stehlin JS, Wall ME, Wani MC, Nicholas AW, Liu LF, Silber R et al (1989) DNA topoisomerase I鈥搕argeted chemotherapy of human colon cancer in xenografts. Science 246:1046鈥?048CrossRef PubMed
  6.Kanzawa F, Sugimoto Y, Minato K, Kasahara K, Bungo M, Nakagawa K, Fujiwara Y et al (1990) Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance. Cancer Res 50:5919鈥?924PubMed
  7.Saleem A, Edwards TK, Rasheed Z, Rubin EH (2000) Mechanisms of resistance to camptothecins. Ann NY Acad Sci 922:46鈥?5CrossRef PubMed
  8.Afzal O, Kumar S, Haider MR, Ali MR, Kumar R, Jaggi M, Bawa S (2015) A review on anticancer potential of bioactive heterocycle quinoline. Eur J Med Chem 97:871鈥?10CrossRef PubMed
  9.Ding Y, Nguyen TA (2013) PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9. Apoptosis 18:1071鈥?082PubMed Central CrossRef PubMed
  10.Sedic M, Poznic M, Gehrig P, Scott M, Schlapbach R, Hranjec M, Karminski-Zamola G et al (2008) Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2-alpha]quinoline in colon cancer cells depending on their p53 status. Mol Cancer Ther 7:2121鈥?132CrossRef PubMed
  11.Souli E, Machluf M, Morgenstern A, Sabo E, Yannai S (2008) Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. Food Chem Toxicol 46:863鈥?70CrossRef PubMed
  12.Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T (2009) A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer 8:100PubMed Central CrossRef PubMed
  13.Chakrabarti G, Basu A, Manna PP, Mahato SB, Mandal NB, Bandyopadhyay S (1999) Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. J Antimicrob Chemother 43:359鈥?66CrossRef PubMed
  14.Pal C, Raha M, Basu A, Roy KC, Gupta A, Ghosh M, Sahu NP et al (2002) Combination therapy with indolylquinoline derivative and sodium antimony gluconate cures established visceral leishmaniasis in hamsters. Antimicrob Agents Chemother 46:259鈥?61PubMed Central CrossRef PubMed
  15.Ramesh C, Kavala V, Raju BR, Kuo C-W, Yao C-F (2009) Novel synthesis of indolylquinoline derivatives via the C-alkylation of Baylis鈥揌illman adducts. Tetrahedron Lett 50:4037鈥?041CrossRef
  16.Wang JP, Lin KH, Liu CY, Yu YC, Wu PT, Chiu CC, Su CL et al (2013) Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53. Toxicol Appl Pharmacol 273:110鈥?20CrossRef PubMed
  17.Weng JR, Bai LY, Chiu CF, Wang YC, Tsai MH (2012) The dietary phytochemical 3,3鈥?diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-魏B, MAPK, and p53 signaling. Chem Biol Interact 195:224鈥?30CrossRef PubMed
  18.Agarwal C, Singh RP, Agarwal R (2002) Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis 23:1869鈥?876CrossRef PubMed
  19.Chipuk JE, Green DR (2008) How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 18:157鈥?64PubMed Central CrossRef PubMed
  20.Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495鈥?16PubMed Central CrossRef PubMed
  21.Lakin ND, Jackson SP (1999) Regulation of p53 in response to DNA damage. Oncogene 18:7644鈥?655CrossRef PubMed
  22.Petty TJ, Emamzadah S, Costantino L, Petkova I, Stavridi ES, Saven JG, Vauthey E et al (2011) An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J 30:2167鈥?176PubMed Central CrossRef PubMed
  23.Burris HA 3rd (2009) Shortcomings of current therapies for non-small-cell lung cancer: unmet medical needs. Oncogene 28(Suppl 1):S4鈥揝13CrossRef PubMed
  24.Aqil M, Elseth KM, Vesper BJ, Deliu Z, Aydogan B, Xue J, Radosevich JA (2014) Part I-mechanism of adaptation: high nitric oxide adapted A549 cells show enhanced DNA damage response and activation of antiapoptotic pathways. Tumour Biol 35:2403鈥?415CrossRef PubMed
  25.Roos WP, Kaina B (2006) DNA damage-induced cell death by apoptosis. Trends Mol Med 12:440鈥?50CrossRef PubMed
  26.Green DR (2005) Apoptotic pathways: ten minutes to dead. Cell 121:671鈥?74CrossRef PubMed
  27.Haupt S, Berger M, Goldberg Z, Haupt Y (2003) Apoptosis: the p53 network. J Cell Sci 116:4077鈥?085CrossRef PubMed
  28.Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Macho A, Haeffner A et al (1996) Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 184:1155鈥?160CrossRef PubMed
  29.Toledo F, Wahl GM (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6:909鈥?23CrossRef PubMed
  30.Wang Y, Ji P, Liu J, Broaddus RR, Xue F, Zhang W (2009) Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy. Mol Cancer 8:8PubMed Central CrossRef PubMed
  31.Chang C, Zhu YQ, Mei JJ, Liu SQ, Luo J (2010) Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells. J Exp Clin Cancer Res 29:145PubMed Central CrossRef PubMed
  32.Bose P, Thakur S, Thalappilly S, Ahn BY, Satpathy S, Feng X, Suzuki K et al (2013) ING1 induces apoptosis through direct effects at the mitochondria. Cell Death Dis 4:e788PubMed Central CrossRef PubMed
  33.Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB, Lu Z (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep 13:554鈥?60PubMed Central CrossRef PubMed
  34.Qian J, Zou Y, Rahman JS, Lu B, Massion PP (2009) Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung. Mol Cancer Ther 8:101鈥?09PubMed Central CrossRef PubMed
  35.Malki A, Ashry el S (2014) In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer. Anticancer Res 34:1367鈥?376PubMed
  36.Pronier E, Levine RL (2015) IDH1/2 mutations and BCL-2 dependence: an unexpected Chink in AML鈥檚 armour. Cancer Cell 27:323鈥?25CrossRef PubMed
  
• 作者单位：Chun-Yen Liu (1)
  Pei-Tsen Wu (1)
  Jing-Ping Wang (1)
  Po-Wei Fan (1)
  Chang-Hung Hsieh (1)
  Chun-Li Su (2)
  Chien-Chih Chiu (3)
  Ching-Fa Yao (4)
  Kang Fang (1)
  
  1. Department of Life Science, National Taiwan Normal University, 88 Ting-Chow Rd, Sec 4, Taipei, 116, Taiwan
  2. Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan
  3. Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
  4. Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Cell Biology
  Biochemistry
  Virology
  
• 出版者：Springer Netherlands
• ISSN：1573-675X

文摘

A number of effective anti-cancer drugs contain either indole or quinoline group. Compounds fused indole and quinoline moieties altogether as indolylquinoline were rarely reported as anti-cancer agents. We reported here that a synthetic indolylquinoline derivative, 3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline (EMMQ), inhibited the growth of human non-small cell lung cancer (NSCLC) cells in dose- and time-dependent manners. The cytotoxicity was mediated through apoptotic cell death that began with mitochondrial membrane potential interruption and DNA damage. EMMQ caused transient elevation of p53 that assists in cytochrome c release, cleavage of downstream PARP and procaspase-3 and mitochondria-related apoptosis. The degree of apoptotic cell death depends on the status of tumor suppressor p53 of the target cells. H1299 cells with stable ectopic expression of p53 induced cytotoxicity by disrupting mitochondria functions that differed with those transfected with mutant p53. Knocking-down of p53 attenuated drug effects. EMMQ suppressed the growth of A549 tumor cells in xenograft tumors by exhibiting apoptosis characteristics. Given its small molecular weight acting as an effective p53 regulator in NSCLC cells, EMMQ could be an addition to the current list of lung cancer treatment. Keywords Indolylquinoline Human non-small-cell-lung-cancer cells Apoptosis RNA interference p53