MicroRNA-dependent genetic networks during neural development

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• 作者：Daniel G. Abernathy (1) (2)
  Andrew S. Yoo (1)
  
  1. Department of Developmental Biology ; Washington University School of Medicine ; St. Louis ; MO ; 63110 ; USA
  2. Program of Developmental ; Regenerative ; and Stem Cell Biology ; Washington University School of Medicine ; St. Louis ; MO ; 63110 ; USA
  
• 关键词：MicroRNAs ; Neural development ; Brain ; Genetic networks ; Direct reprogramming ; Epigenetics
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：359
• 期：1
• 页码：179-185
• 全文大小：1,882 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

The development of the structurally and functionally diverse mammalian nervous system requires the integration of numerous levels of gene regulation. Accumulating evidence suggests that microRNAs are key mediators of genetic networks during neural development. Importantly, microRNAs are found to regulate both feedback and feedforward loops during neural development leading to large changes in gene expression. These repressive interactions provide an additional mechanism that facilitates the establishment of complexity within the nervous system. Here, we review studies that have enabled the identification of microRNAs enriched in the brain and discuss the way that genetic networks in neural development depend on microRNAs.