A WD40-repeat protein unique to malaria parasites associates with adhesion protein complexes and is crucial for blood stage progeny
详细信息 查看全文
- 作者：Andreas von Bohl ; Andrea Kuehn ; Nina Simon ; Vanesa Nkwouano Ngongang…
- 关键词：Malaria ; Plasmodium falciparum ; Merozoite ; Microneme ; Gametocyte ; WD40 ; PfAMA1 ; Pfs230 ; PfCCp protein
- 刊名：Malaria Journal
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：14
- 期：1
- 全文大小：3,357 KB
- 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine;
- 出版者：BioMed Central
- ISSN：1475-2875
文摘
Background During development in human erythrocytes, Plasmodium falciparum parasites display a remarkable number of adhesive proteins on their plasma membrane. In the invasive merozoites, these include members of the PfMSP1 and PfAMA1/RON complexes, which facilitate contact between merozoites and red blood cells. In gametocytes, sexual precursor cells mediating parasite transmission to the mosquito vector, plasma membrane-associated proteins primarily belong to the PfCCp and 6-cys families with roles in fertilization. This study describes a newly identified WD40-repeat protein unique to Plasmodium species that associates with adhesion protein complexes of both merozoites and gametocytes.