Influence of phthalates on glucose homeostasis and atherosclerosis in hyperlipidemic mice

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• 作者：Wei Zhou ; Mei-Hua Chen ; Weibin SHI
• 关键词：Phthalates ; Type 2 diabetes ; Atherosclerosis ; Dyslipidemia ; Mice
• 刊名：BMC Endocrine Disorders
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：916 KB
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• 刊物主题：Endocrinology; Metabolic Diseases; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1472-6823

文摘

Background Phthalates are widely used as plasticizer and are considered as a typical endocrine-disrupting chemical. Epidemiological studies have associated serum or urinary phthalate metabolites with the prevalence of type 2 diabetes or related phenotypes. However, direct evidence supporting a causal role for exposure to phthalates in type 2 diabetes is lacking. Methods To determine the potential influence of phthalates on glucose homeostasis and atherosclerosis, female apolipoprotein E-deficient (Apoe??/sup>) mice were started at 6?weeks of age on a Western diet together with or without Bis-(2-ethylhexyl) phthalate. Phthalate was administered in drinking water at a daily dosage of 100?mg/kg. We examined glucose and insulin tolerance, plasma glucose and triglyceride levels, body weight, and atherosclerotic lesions in the aortic root. Results Two weeks after treatment, phthalate-exposed mice had significantly higher fasting blood glucose level (97.9?±-.1 vs. 84.3?±-.3?mg/dl, P--.034) and exhibited a trend of increased glucose intolerance compared to control mice. Insulin tolerance test on non-fasted mice 3?weeks after treatment revealed that phthalate had little influence on insulin sensitivity though phthalate-treated mice had a higher glucose concentration (159.2?±-.0 vs. 145.2?±-.6?mg/dl; P--.086). On the Western diet, Apoe??/sup> mice showed a time-dependent rise in fasting plasma glucose and triglyceride levels. However, no significant differences were observed between phthalate-treated and control mice in either phenotype after 4, 8, and 12?weeks of phthalate exposure. Neither body weight nor atherosclerotic lesions of Apoe??/sup> mice was affected. Conclusion This study indicates that exposure to phthalates gives rise to a brief interference of glucose homeostasis but has little impact on the development of type 2 diabetes and atherosclerosis in Apoe??/sup> mice.