DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations
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- 作者：Yuchen Yuan ; Yi Shi ; Changyang Li ; Jinman Kim ; Weidong Cai…
- 刊名：BMC Bioinformatics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：17-supp
- 全文大小：1720KB
- 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
- 出版者：BioMed Central
- ISSN：1471-2105
- 卷排序：17
文摘
BackgroundWith the developments of DNA sequencing technology, large amounts of sequencing data have become available in recent years and provide unprecedented opportunities for advanced association studies between somatic point mutations and cancer types/subtypes, which may contribute to more accurate somatic point mutation based cancer classification (SMCC). However in existing SMCC methods, issues like high data sparsity, small volume of sample size, and the application of simple linear classifiers, are major obstacles in improving the classification performance.