Quantitative framework for ordered degradation of APC/C substrates
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- 作者：Dan Lu ; Juliet R. Girard ; Weihan Li ; Arda Mizrak ; David O. Morgan
- 关键词：Cell cycle ; Anaphase ; APC/C ; Cdc20 ; Model ; Clb5 ; Securin ; Ubiquitin
- 刊名：BMC Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：13
- 期：1
- 全文大小：2,753 KB
- 刊物主题：Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1741-7007
文摘
Background During cell-cycle progression, substrates of a single master regulatory enzyme can be modified in a specific order. Here, we used experimental and computational approaches to dissect the quantitative mechanisms underlying the ordered degradation of the substrates of the ubiquitin ligase APC/CCdc20, a key regulator of chromosome segregation in mitosis.