The Significance of Preoperative Chemotherapy in Evaluation of Recurrent Soft Tissue Liposarcoma Necrosis

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• 作者：Qiu Cui (1)
  Dingfeng Li (1)
  Jing Zhang (2)
  Xiaohong Wang (2)
  Shubin Liu (1)
  Lei Wang (1)
  Ping Zhang (1)
  Ju Zhou (1)
  Cheng Liu (1)
  Weihao Jiang (1)
  Yanjun Zeng (2)
  
• 关键词：Implantable intra ; arterial induction chemotherapy ; Liposarcoma ; Cisplatin ; Doxorubicin ; Caffeine
• 刊名：Pathology & Oncology Research
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：18
• 期：3
• 页码：629-633
• 全文大小：567KB
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• 作者单位：Qiu Cui (1)
  Dingfeng Li (1)
  Jing Zhang (2)
  Xiaohong Wang (2)
  Shubin Liu (1)
  Lei Wang (1)
  Ping Zhang (1)
  Ju Zhou (1)
  Cheng Liu (1)
  Weihao Jiang (1)
  Yanjun Zeng (2)
  
  1. Department of Bone Tumor, 307th Hospital of PLA, Beijing, 100071, People’s Republic of China
  2. Biomedical Engineering Center, Beijing University of Technology, Beijing, 100022, China
  
• ISSN：1532-2807

文摘

To investigate the effect of preoperative induction chemotherapy on treatment of recurrent liposarcoma. 21 patients with recurrent liposarcoma received the treatment of preoperative intra-arterial chemotherapy and surgical resection. Intra-arterial chemotherapy was given by subcutaneous implantable drug delivery system with infusion of cisplatin and doxorubicin followed by caffeine. After treatment, patients were followed up for 39?months. The liposarcoma changes in CT imaging were observed in 18 cases and there were 15 cases with medium or severe pathological changes caused by chemotherapy. At the end of the postoperative follow-up of 39?months, liposarcoma reoccurred locally in 2 cases; pulmonary metastasis occurred in 1 case and death in 3 cases. Preoperative intra-arterial chemotherapy is effective for highly malignant tumors such as recurrent liposarcoma and the judgment of prognosis is based on the postoperative pathological changes of such tumor.