Effect of BRMS1 on Tumorigenicity and Metastasis of Human Rectal Cancer
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- 作者：Yi Zhang (1)
Jie Guan (1)
Yanlai Sun (1)
Jie Chai (1)
Tao Zou (1)
Weipeng Gong (1)
Zhenyu Zhu (1)
Xin Liu (1)
Qingsheng Hou (1)
Xilin Song (1) - 关键词：BRSM1 ; Rectal cancer ; Metastasis
- 刊名：Cell Biochemistry and Biophysics
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：70
- 期：1
- 页码：505-509
- 全文大小：362 KB
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Jie Guan (1)
Yanlai Sun (1)
Jie Chai (1)
Tao Zou (1)
Weipeng Gong (1)
Zhenyu Zhu (1)
Xin Liu (1)
Qingsheng Hou (1)
Xilin Song (1)
1. Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, 250017, China - ISSN：1559-0283
文摘
Breast cancer metastasis suppressor gene-1 (BRMS1) is newly discovered tumor metastasis gene, which has been reported to play an important role in the progression of human tumor. However, its role in rectal cancer has never been investigated. In this present study, we evaluated the associated of BRMS1 with colorectal cancer, its value in prognosis, and its role in metastasis of rectal cancer. BRMS1 expression examined in 80 patients and the role of BRMS1 in metastasis was studied using mice model. Our results showed that BRMS1 expression was significantly associated with clinicopathological parameters in rectal cancer patients and overexpression of BRMS1 in rectal cancer xenograft led to decreased growth, invasiveness and metastasis. Our findings indicate that high expression of BRSM1 in rectal cancer plays an essential role in tumor progression.